SSBP1

From Wikipedia, the free encyclopedia

Single-stranded DNA binding protein 1

PDB rendering based on 1s3o.

Available structures: 1s3o, 2dud, 3ull

Identifiers

Symbol(s)

SSBP1; SSBP

External IDs

OMIM: 600439 MGI: 1920040 HomoloGene: 74462

Gene ontology
Molecular Function:	• DNA binding • single-stranded DNA binding
Cellular Component:	• mitochondrion
Biological Process:	• DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003143 (mRNA)
NP_003134 (protein)

NM_028358 (mRNA)
NP_082634 (protein)

Location

Chr 7: 141.08 - 141.1 Mb

Chr 6: 40.4 - 40.41 Mb

Pubmed search

[1]

[2]

Single-stranded DNA binding protein 1, also known as SSBP1, is a human gene.^[1]

SSBP is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SSBP1 single-stranded DNA binding protein 1.

[edit] Further reading

Tiranti V, Rossi E, Ruiz-Carrillo A, et al. (1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis.". Genomics 25 (2): 559–64. PMID 7789991.
Tiranti V, Rocchi M, DiDonato S, Zeviani M (1993). "Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB).". Gene 126 (2): 219–25. PMID 8482537.
Yang C, Curth U, Urbanke C, Kang C (1997). "Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution.". Nat. Struct. Biol. 4 (2): 153–7. PMID 9033597.
Schultz RA, Swoap SJ, McDaniel LD, et al. (1998). "Differential expression of mitochondrial DNA replication factors in mammalian tissues.". J. Biol. Chem. 273 (6): 3447–51. PMID 9452467.
Spelbrink JN, Toivonen JM, Hakkaart GA, et al. (2000). "In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells.". J. Biol. Chem. 275 (32): 24818–28. doi:10.1074/jbc.M000559200. PMID 10827171.
Müller-Höcker J, Schäfer S, Li K (2002). "Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue.". Appl. Immunohistochem. Mol. Morphol. 9 (3): 276–80. PMID 11556757.
Takamatsu C, Umeda S, Ohsato T, et al. (2002). "Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein.". EMBO Rep. 3 (5): 451–6. doi:10.1093/embo-reports/kvf099. PMID 11964388.
Chen L, Segal D, Hukriede NA, et al. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–5. doi:10.1073/pnas.212532399. PMID 12381786.
Diez-Tascón C, Dodds KG, Crawford AM (2003). "Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7.". Anim. Genet. 33 (6): 468. PMID 12464025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bayarsaihan D (2003). "SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain.". Biochim. Biophys. Acta 1599 (1-2): 152–5. PMID 12479417.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Pocernich CB, Poon HF, Boyd-Kimball D, et al. (2005). "Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat.". Brain Res. Mol. Brain Res. 133 (2): 299–306. doi:10.1016/j.molbrainres.2004.10.024. PMID 15710247.