SS18

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Synovial sarcoma translocation, chromosome 18
Identifiers
Symbol(s) SS18; MGC116875; SSXT; SYT
External IDs OMIM: 600192 MGI: 107708 HomoloGene: 38080
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6760 268996
Ensembl ENSG00000141380 ENSMUSG00000037013
Uniprot Q15532 Q3TM96
Refseq NM_001007559 (mRNA)
NP_001007560 (protein)		 NM_009280 (mRNA)
NP_033306 (protein)
Location Chr 18: 21.85 - 21.92 Mb Chr 18: 14.77 - 14.83 Mb
Pubmed search [1] [2]

Synovial sarcoma translocation, chromosome 18, also known as SS18, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: SS18 synovial sarcoma translocation, chromosome 18.

[edit] Further reading

  • Fligman I, Lonardo F, Jhanwar SC, et al. (1996). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript.". Am. J. Pathol. 147 (6): 1592-9. PMID 7495284. 
  • Clark J, Rocques PJ, Crew AJ, et al. (1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.". Nat. Genet. 7 (4): 502-8. doi:10.1038/ng0894-502. PMID 7951320. 
  • Shipley JM, Clark J, Crew AJ, et al. (1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome.". Oncogene 9 (5): 1447-53. PMID 8152806. 
  • Brett D, Whitehouse S, Antonson P, et al. (1998). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies.". Hum. Mol. Genet. 6 (9): 1559-64. PMID 9285794. 
  • Thaete C, Brett D, Monaghan P, et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.". Hum. Mol. Genet. 8 (4): 585-91. PMID 10072425. 
  • Eid JE, Kung AL, Scully R, Livingston DM (2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion.". Cell 102 (6): 839-48. PMID 11030627. 
  • Tamborini E, Agus V, Mezzelani A, et al. (2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma.". Br. J. Cancer 84 (8): 1087-94. doi:10.1054/bjoc.2000.1710. PMID 11308259. 
  • Brodin B, Haslam K, Yang K, et al. (2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression.". Gene 268 (1-2): 173-82. PMID 11368913. 
  • de Bruijn DR, dos Santos NR, Thijssen J, et al. (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10.". Oncogene 20 (25): 3281-9. doi:10.1038/sj.onc.1204419. PMID 11423977. 
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653. 
  • Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498-505. doi:10.1074/jbc.M108702200. PMID 11734557. 
  • Yang K, Lui WO, Xie Y, et al. (2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.". Oncogene 21 (26): 4181-90. doi:10.1038/sj.onc.1205569. PMID 12037676. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35-50. PMID 12878157. 
  • Perani M, Ingram CJ, Cooper CS, et al. (2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.". Oncogene 22 (50): 8156-67. doi:10.1038/sj.onc.1207031. PMID 14603256. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Iwasaki T, Koibuchi N, Chin WW (2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.". Endocrinology 146 (9): 3892-9. doi:10.1210/en.2004-1513. PMID 15919756. 
  • Fernebro J, Francis P, Edén P, et al. (2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma.". Int. J. Cancer 118 (5): 1165-72. doi:10.1002/ijc.21475. PMID 16152617. 
  • Perani M, Antonson P, Hamoudi R, et al. (2006). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins.". J. Biol. Chem. 280 (52): 42863-76. doi:10.1074/jbc.M502963200. PMID 16227627. 
  • Sun Y, Gao D, Liu Y, et al. (2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.". Oncogene 25 (7): 1042-52. doi:10.1038/sj.onc.1209143. PMID 16247461. 
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