SRPK2

From Wikipedia, the free encyclopedia

SFRS protein kinase 2

Identifiers

SRPK2; FLJ36101; SFRSK2

External IDs

OMIM: 602980 MGI: 1201408 HomoloGene: 40660

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• spliceosome assembly • mRNA processing • protein amino acid phosphorylation • protein kinase cascade • RNA splicing • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_182691 (mRNA)
NP_872633 (protein)

NM_009274 (mRNA)
NP_033300 (protein)

Location

Chr 7: 104.54 - 104.82 Mb

Chr 5: 23.02 - 23.08 Mb

Pubmed search

[1]

[2]

SFRS protein kinase 2, also known as SRPK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SRPK2 SFRS protein kinase 2.

[edit] Further reading

Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle.". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMID 9171351.
Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M (1998). "Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.". Biochem. Biophys. Res. Commun. 242 (2): 357–64. doi:10.1006/bbrc.1997.7913. PMID 9446799.
Wang HY, Lin W, Dyck JA, et al. (1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.". J. Cell Biol. 140 (4): 737–50. PMID 9472028.
Koizumi J, Okamoto Y, Onogi H, et al. (1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs).". J. Biol. Chem. 274 (16): 11125–31. PMID 10196197.
Daub H, Blencke S, Habenberger P, et al. (2002). "Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.". J. Virol. 76 (16): 8124–37. PMID 12134018.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Zheng Y, Fu XD, Ou JH (2005). "Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.". Virology 342 (1): 150–8. doi:10.1016/j.virol.2005.07.030. PMID 16122776.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.