SRI (gene)

From Wikipedia, the free encyclopedia

Sorcin

PDB rendering based on 1gjy.

Available structures: 1gjy, 1juo

Identifiers

Symbol(s)

SRI; FLJ26259; SCN

External IDs

OMIM: 182520 MGI: 98419 HomoloGene: 37736

Gene ontology
Molecular Function:	• receptor binding • calcium channel regulator activity • calcium ion binding
Cellular Component:	• intracellular • cytoplasm • plasma membrane
Biological Process:	• regulation of action potential • transport • intracellular sequestering of iron ion • regulation of striated muscle contraction • signal transduction • heart development • muscle development • regulation of heart contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003130 (mRNA)
NP_003121 (protein)

XM_980298 (mRNA)
XP_985392 (protein)

Location

Chr 7: 87.67 - 87.69 Mb

Chr 5: 8.05 - 8.07 Mb

Pubmed search

[1]

[2]

Sorcin, also known as SRI, is a human gene.^[1]

[edit] References

^ Entrez Gene: SRI sorcin.

[edit] Further reading

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667.
Van der Bliek AM, Baas F, Van der Velde-Koerts T, et al. (1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines.". Cancer Res. 48 (21): 5927–32. PMID 2901906.
Meyers MB, Pickel VM, Sheu SS, et al. (1995). "Association of sorcin with the cardiac ryanodine receptor.". J. Biol. Chem. 270 (44): 26411–8. PMID 7592856.
Meyers MB, Zamparelli C, Verzili D, et al. (1995). "Calcium-dependent translocation of sorcin to membranes: functional relevance in contractile tissue.". FEBS Lett. 357 (3): 230–4. PMID 7835417.
Wang SL, Tam MF, Ho YS, et al. (1995). "Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells.". Biochim. Biophys. Acta 1260 (3): 285–93. PMID 7873602.
Lee WP (1996). "Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines.". Arch. Biochem. Biophys. 325 (2): 217–26. doi:10.1006/abbi.1996.0027. PMID 8561500.
Brownawell AM, Creutz CE (1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII).". J. Biol. Chem. 272 (35): 22182–90. PMID 9268363.
Torigoe K, Harada T, Kusaba H, et al. (1998). "Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1.". Genomics 49 (1): 14–22. doi:10.1006/geno.1997.5200. PMID 9570944.
Meyers MB, Puri TS, Chien AJ, et al. (1998). "Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels.". J. Biol. Chem. 273 (30): 18930–5. PMID 9668070.
Pack-Chung E, Meyers MB, Pettingell WP, et al. (2000). "Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.". J. Biol. Chem. 275 (19): 14440–5. PMID 10748169.
Xie X, Dwyer MD, Swenson L, et al. (2002). "Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.". Protein Sci. 10 (12): 2419–25. PMID 11714909.
Li G, Tan Y, Yang C, et al. (2003). "Expression and clinical implication of soluble resistance-associated calcium-binding protein gene and multi-drug resistance gene in leukemia.". Zhonghua Zhong Liu Za Zhi 24 (4): 370–4. PMID 12408767.
Li G, Tan Y, Yang C, et al. (2002). "Expression and clinical implications of the soluble drug resistance-related calcium-binding protein (sorcin) gene in leukemia patients.". Zhonghua Xue Ye Xue Za Zhi 23 (6): 293–6. PMID 12411058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Meyers MB, Fischer A, Sun YJ, et al. (2003). "Sorcin regulates excitation-contraction coupling in the heart.". J. Biol. Chem. 278 (31): 28865–71. doi:10.1074/jbc.M302009200. PMID 12754254.
Hansen C, Tarabykina S, la Cour JM, et al. (2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.". FEBS Lett. 545 (2-3): 151–4. PMID 12804766.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Frank KF, Bölck B, Ding Z, et al. (2005). "Overexpression of sorcin enhances cardiac contractility in vivo and in vitro.". J. Mol. Cell. Cardiol. 38 (4): 607–15. doi:10.1016/j.yjmcc.2005.01.011. PMID 15808837.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.