SPRR2A

From Wikipedia, the free encyclopedia

Small proline-rich protein 2A

Identifiers

External IDs

OMIM: 182267 MGI: 1330344 HomoloGene: 31413

Gene ontology
Molecular Function:	• structural molecule activity • binding • protein binding
Cellular Component:	• cornified envelope • cytoplasm
Biological Process:	• embryo implantation • epidermis development • keratinocyte differentiation • keratinization • menstrual cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005988 (mRNA)
NP_005979 (protein)

NM_011477 (mRNA)
NP_035607 (protein)

Location

Chr 1: 151.3 - 151.3 Mb

Chr 3: 92.52 - 92.52 Mb

Pubmed search

[1]

[2]

Small proline-rich protein 2A, also known as SPRR2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPRR2A small proline-rich protein 2A.

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Tong L, Corrales RM, Chen Z, et al. (2006). "Expression and regulation of cornified envelope proteins in human corneal epithelium.". Invest. Ophthalmol. Vis. Sci. 47 (5): 1938–46. doi:10.1167/iovs.05-1129. PMID 16639001.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.". Mol. Cells 17 (3): 477–84. PMID 15232223.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. PMID 12624109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Fischer DF, van Drunen CM, Winkler GS, et al. (1999). "Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker.". Nucleic Acids Res. 26 (23): 5288–94. PMID 9826750.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895.
Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996). "Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation.". Mol. Cell. Biol. 16 (10): 5365–74. PMID 8816448.
Gibbs S, Fijneman R, Wiegant J, et al. (1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.". Genomics 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
Gibbs S, Lohman F, Teubel W, et al. (1990). "Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.". Nucleic Acids Res. 18 (15): 4401–7. PMID 2388825.