Sphingosine N-acyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a sphingosine N-acyltransferase (EC 2.3.1.24) is an enzyme that catalyzes the chemical reaction

acyl-CoA + sphingosine CoA + N-acylsphingosine

Thus, the two substrates of this enzyme are acyl-CoA and sphingosine, whereas its two products are CoA and N-acylsphingosine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sphingosine N-acyltransferase. Other names in common use include ceramide synthetase, and sphingosine acyltransferase. This enzyme participates in sphingolipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.24
• BRENDA references for 2.3.1.24 (Recommended.)
• PubMed references for 2.3.1.24
• PubMed Central references for 2.3.1.24
• Google Scholar references for 2.3.1.24
• Sribney M (1966). "Enzymatic synthesis of ceramide". Biochim. Biophys. Acta. 125: 542–7. PMID 5973195. 

[edit] External links

The CAS registry number for this enzyme class is 37257-09-3.

• IUBMB entry for 2.3.1.24

• KEGG entry for 2.3.1.24

• BRENDA entry for 2.3.1.24

• NiceZyme view of 2.3.1.24

• EC2PDB: PDB structures for 2.3.1.24

• PRIAM entry for 2.3.1.24

• PUMA2 entry for 2.3.1.24

• IntEnz: Integrated Enzyme entry for 2.3.1.24

• MetaCyc entry for 2.3.1.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050291: sphingosine N-acyltransferase

• AMIGO entry for GO code 0050291: sphingosine N-acyltransferase