Sphingomyelin synthase

From Wikipedia, the free encyclopedia

In enzymology, a sphingomyelin synthase (EC 2.7.8.27) is an enzyme that catalyzes the chemical reaction

a ceramide + a phosphatidylcholine $\rightleftharpoons$ a sphingomyelin + a 1,2-diacyl-sn-glycerol

Thus, the two substrates of this enzyme are ceramide and phosphatidylcholine, whereas its two products are sphingomyelin and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is ceramide:phosphatidylcholine cholinephosphotransferase. Other names in common use include SM synthase, SMS1, and SMS2.

[edit] References

IUBMB entry for 2.7.8.27
BRENDA references for 2.7.8.27 (Recommended.)
PubMed references for 2.7.8.27
PubMed Central references for 2.7.8.27
Google Scholar references for 2.7.8.27
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Tafesse FG, Ternes P, Holthuis JC (2006). "The multigenic sphingomyelin synthase family". J. Biol. Chem. 281: 29421–5. doi:10.1074/jbc.R600021200. PMID 16905542.
Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T (2004). "Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells". J. Biol. Chem. 279: 18688–93. doi:10.1074/jbc.M401205200. PMID 14976195.