SPEG

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SPEG complex locus
PDB rendering based on 1u2h.
Available structures: 1u2h
Identifiers
Symbol(s) SPEG; APEG1; BPEG; KIAA1297; MGC12676; SPEGalpha; SPEGbeta
External IDs HomoloGene: 89808
Orthologs
Human Mouse
Entrez 10290 n/a


Refseq XM_001128413 (mRNA)
XP_001128413 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

SPEG complex locus, also known as SPEG, is a human gene.[1]

Expression of this gene is thought to serve as a marker for differentiated vascular smooth muscle cells which may have a role in regulating growth and differentiation of this cell type. The encoded protein is highly similar to the corresponding rat and mouse proteins. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of only one variant has been defined.[1]

[edit] References

  1. ^ a b Entrez Gene: SPEG SPEG complex locus.

[edit] Further reading

  • Hsieh CM, Yoshizumi M, Endege WO, et al. (1996). "APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.". J. Biol. Chem. 271 (29): 17354–9. PMID 8663449. 
  • Hsieh CM, Yet SF, Layne MD, et al. (1999). "Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif.". J. Biol. Chem. 274 (20): 14344–51. PMID 10318857. 
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Sutter SB, Raeker MO, Borisov AB, Russell MW (2005). "Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.". Dev. Genes Evol. 214 (7): 352–9. doi:10.1007/s00427-004-0413-5. PMID 15185077. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Arvanitis DA, Flouris GA, Spandidos DA (2005). "Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis.". J. Cell. Mol. Med. 9 (1): 153–9. PMID 15784173. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Manjasetty BA, Niesen FH, Scheich C, et al. (2006). "X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1).". BMC Struct. Biol. 5: 21. doi:10.1186/1472-6807-5-21. PMID 16354304. 
  • Tam JL, Triantaphyllopoulos K, Todd H, et al. (2006). "The human desmin locus: gene organization and LCR-mediated transcriptional control.". Genomics 87 (6): 733–46. doi:10.1016/j.ygeno.2006.01.009. PMID 16545539. 
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