SPDEF

From Wikipedia, the free encyclopedia

SAM pointed domain containing ets transcription factor

PDB rendering based on 1yo5.

Available structures: 1yo5, 2dkx

Identifiers

Symbol(s)

SPDEF; PDEF; RP11-375E1__A.3; bA375E1.3

External IDs

OMIM: 608144 MGI: 1353422 HomoloGene: 8231

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012391 (mRNA)
NP_036523 (protein)

NM_013891 (mRNA)
NP_038919 (protein)

Location

Chr 6: 34.61 - 34.63 Mb

Chr 17: 27.44 - 27.46 Mb

Pubmed search

[1]

[2]

SAM pointed domain containing ets transcription factor, also known as SPDEF, is a human gene.^[1]

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor.

[edit] Further reading

Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions.". Comparative biochemistry and physiology. A, Comparative physiology 53 (3): 285–9. PMID 2437.
Johannessen JV, Finseth I (1983). "Electron micrographs in five minutes.". Ultrastructural pathology 4 (1): 97–100. PMID 6857767.
Oettgen P, Finger E, Sun Z, et al. (2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.". J. Biol. Chem. 275 (2): 1216–25. PMID 10625666.
Yamada N, Tamai Y, Miyamoto H, Nozaki M (2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member.". Gene 241 (2): 267–74. PMID 10675039.
Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.". Cancer Res. 62 (2): 338–40. PMID 11809674.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Thompson HG, Harris JW, Wold BJ, et al. (2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.". Oncogene 22 (15): 2322–33. doi:10.1038/sj.onc.1206325. PMID 12700667.
Feldman RJ, Sementchenko VI, Gayed M, et al. (2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression.". Cancer Res. 63 (15): 4626–31. PMID 12907642.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ghadersohi A, Odunsi K, Lele S, et al. (2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules.". Oncol. Rep. 11 (2): 453–8. PMID 14719083.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673.
Wang Y, Feng L, Said M, et al. (2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.". Biochemistry 44 (19): 7095–106. doi:10.1021/bi047352t. PMID 15882048.
Fowler M, Borazanci E, McGhee L, et al. (2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region.". J. Cell. Biochem. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID 16237704.
Gunawardane RN, Sgroi DC, Wrobel CN, et al. (2006). "Novel role for PDEF in epithelial cell migration and invasion.". Cancer Res. 65 (24): 11572–80. doi:10.1158/0008-5472.CAN-05-1196. PMID 16357167.
Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, et al. (2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors.". Int. J. Gynecol. Pathol. 26 (1): 10–5. doi:10.1097/01.pgp.0000225386.41244.bd. PMID 17197890.
Park KS, Korfhagen TR, Bruno MD, et al. (2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium.". J. Clin. Invest. 117 (4): 978–88. doi:10.1172/JCI29176. PMID 17347682.