SP7

From Wikipedia, the free encyclopedia

Sp7 transcription factor

Identifiers

SP7; OSX; MGC126598; osterix

External IDs

OMIM: 606633 MGI: 2153568 HomoloGene: 15607

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • transcription regulator activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• osteoblast differentiation • transcription • regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_152860 (mRNA)
NP_690599 (protein)

NM_130458 (mRNA)
NP_569725 (protein)

Location

Chr 12: 52.01 - 52.01 Mb

Chr 15: 102.19 - 102.19 Mb

Pubmed search

[1]

[2]

Sp7 transcription factor, also known as SP7, is a human gene.^[1]

SP7 is a C2H2-type zinc finger transcription factor of the SP gene family and a putative master regulator of bone cell differentiation (Gao et al., 2004).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SP7 Sp7 transcription factor.

[edit] Further reading

Nakashima K, Zhou X, Kunkel G, et al. (2002). "The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.". Cell 108 (1): 17–29. PMID 11792318.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gronthos S, Chen S, Wang CY, et al. (2003). "Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin.". J. Bone Miner. Res. 18 (4): 716–22. PMID 12674332.
Milona MA, Gough JE, Edgar AJ (2004). "Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells.". BMC Genomics 4 (1): 43. doi:10.1186/1471-2164-4-43. PMID 14604442.
Gao Y, Jheon A, Nourkeyhani H, et al. (2005). "Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene.". Gene 341: 101–10. doi:10.1016/j.gene.2004.05.026. PMID 15474293.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Morsczeck C (2006). "Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro.". Calcif. Tissue Int. 78 (2): 98–102. doi:10.1007/s00223-005-0146-0. PMID 16467978.
Wu L, Wu Y, Lin Y, et al. (2007). "Osteogenic differentiation of adipose derived stem cells promoted by overexpression of osterix.". Mol. Cell. Biochem. 301 (1-2): 83–92. doi:10.1007/s11010-006-9399-9. PMID 17206379.
Amorim BR, Okamura H, Yoshida K, et al. (2007). "The transcriptional factor Osterix directly interacts with RNA helicase A.". Biochem. Biophys. Res. Commun. 355 (2): 347–51. doi:10.1016/j.bbrc.2007.01.150. PMID 17303075.
Fan D, Chen Z, Wang D, et al. (2007). "Osterix is a key target for mechanical signals in human thoracic ligament flavum cells.". J. Cell. Physiol. 211 (3): 577–84. doi:10.1002/jcp.21016. PMID 17311298.
Zheng L, Iohara K, Ishikawa M, et al. (2007). "Runx3 negatively regulates Osterix expression in dental pulp cells.". Biochem. J. 405 (1): 69–75. doi:10.1042/BJ20070104. PMID 17352693.