Talk:Sotalol

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"Sotalol is contraindicated in the setting of decreased ejection fraction due to ischemic heart disease."

In my opinion, the sentence is at best simplistic. It is certainly not the logical conclusion of the reference. 'Regular' sotalol is composed of D and L isomers as a racemic mixture. Both isomers have class III activity, but only the L isomer has class II activity. The study specifically chose the D isomer to exclude beta-blocker activity. However the benefits of beta blockade in acute MI are well-known.

While beta-blockers are not indicated in acute LVF, they are useful in stable disease. [Metoprolol, carvedilol and bisoprolol certainly are, and this probably represents a class effect.] Axl 12:21, 15 Nov 2004 (UTC)