Sortilin 1

From Wikipedia, the free encyclopedia

Sortilin 1

Identifiers

SORT1; NT3; Gp95

External IDs

OMIM: 602458 MGI: 1338015 HomoloGene: 39282

Gene ontology
Molecular Function:	• receptor activity • neurotensin receptor activity, G-protein coupled
Cellular Component:	• lysosome • endosome • endoplasmic reticulum • membrane • integral to membrane • trans-Golgi network transport vesicle
Biological Process:	• ossification • transport • endocytosis • multicellular organismal development • biological_process • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002959 (mRNA)
NP_002950 (protein)

NM_019972 (mRNA)
NP_064356 (protein)

Location

Chr 1: 109.65 - 109.74 Mb

Chr 3: 108.41 - 108.49 Mb

Pubmed search

[1]

[2]

Sortilin 1, also known as SORT1, is a human gene.^[1]

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.^[1]

[edit] See also

Neurotensin receptor

[edit] References

^ ^a ^b Entrez Gene: SORT1 sortilin 1.

[edit] Further reading

Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors.". Trends Pharmacol. Sci. 20 (7): 302-9. PMID 10390649.
Mazella J (2001). "Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?". Cell. Signal. 13 (1): 1-6. PMID 11257441.
Petersen CM, Nielsen MS, Nykjaer A, et al. (1997). "Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.". J. Biol. Chem. 272 (6): 3599-605. PMID 9013611.
Lin BZ, Pilch PF, Kandror KV (1997). "Sortilin is a major protein component of Glut4-containing vesicles.". J. Biol. Chem. 272 (39): 24145-7. PMID 9305862.
Tauris J, Ellgaard L, Jacobsen C, et al. (1998). "The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.". FEBS Lett. 429 (1): 27-30. PMID 9657377.
Mazella J, Zsürger N, Navarro V, et al. (1998). "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor.". J. Biol. Chem. 273 (41): 26273-6. PMID 9756851.
Munck Petersen C, Nielsen MS, Jacobsen C, et al. (1999). "Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.". EMBO J. 18 (3): 595-604. doi:10.1093/emboj/18.3.595. PMID 9927419.
Nielsen MS, Jacobsen C, Olivecrona G, et al. (1999). "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.". J. Biol. Chem. 274 (13): 8832-6. PMID 10085125.
Nielsen MS, Madsen P, Christensen EI, et al. (2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.". EMBO J. 20 (9): 2180-90. doi:10.1093/emboj/20.9.2180. PMID 11331584.
Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.". J. Biol. Chem. 276 (30): 28541-5. doi:10.1074/jbc.C100218200. PMID 11390366.
Hampe W, Rezgaoui M, Hermans-Borgmeyer I, Schaller HC (2001). "The genes for the human VPS10 domain-containing receptors are large and contain many small exons.". Hum. Genet. 108 (6): 529-36. PMID 11499680.
Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.". Nature 415 (6874): 937-41. doi:10.1038/415937a. PMID 11859376.
Maeda S, Nobukuni T, Shimo-Onoda K, et al. (2002). "Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization.". J. Cell. Physiol. 193 (1): 73-9. doi:10.1002/jcp.10151. PMID 12209882.
Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.". Gastroenterology 123 (4): 1135-43. PMID 12360476.
Navarro V, Vincent JP, Mazella J (2003). "Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line.". Biochem. Biophys. Res. Commun. 298 (5): 760-4. PMID 12419319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Martin S, Vincent JP, Mazella J (2003). "Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia.". J. Neurosci. 23 (4): 1198-205. PMID 12598608.
Lefrancois S, Zeng J, Hassan AJ, et al. (2004). "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.". EMBO J. 22 (24): 6430-7. doi:10.1093/emboj/cdg629. PMID 14657016.