Sorangium cellulosum

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Sorangium cellulosum is a soil-dwelling Gram-negative bacteria of the group myxobacteria.[1] It is motile and shows gliding motility. It has an unusually-large genome 12,200,000 base pairs in size.[2] A more recent work sequenced the genome of Sorangium cellulosum So ce56 and put its size at 13033779 base pairs making it the largest bacterial genome sequenced to date.[3]

[edit] Clinical use

Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity. This has led to the development of analogs which mimic its activity. One such analog, known as Ixabepilone is a US FDA approved chemotherapy agent for the treatment of metastatic breast cancer.[1]

[edit] References

  1. ^ Julien B, Fehd R (2003). "Development of a mariner-based transposon for use in Sorangium cellulosum.". Appl Environ Microbiol 69 (10): 6299–301. doi:10.1128/AEM.69.10.6299-6301.2003. PMID 14532095. 
  2. ^ Pradella S, Hans A, Spröer C, Reichenbach H, Gerth K, Beyer S (2002). "Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56.". Arch Microbiol 178 (6): 484–92. doi:10.1007/s00203-002-0479-2. PMID 12420170. 
  3. ^ Schneiker S et al. (2007). "Complete genome sequence of the myxobacterium Sorangium cellulosum". Nature Biotechnology 25 (11): 1281–1289. doi:10.1038/nbt1354. 
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