SNX9

From Wikipedia, the free encyclopedia

Sorting nexin 9

Identifiers

SNX9; SDP1; MST155; MSTP155; SH3PX1; SH3PXD3A; WISP

External IDs

OMIM: 605952 MGI: 1913866 HomoloGene: 49454

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein binding • phosphoinositide binding
Cellular Component:	• soluble fraction • cytoplasm • microsome • plasma membrane
Biological Process:	• intracellular protein transport • cell communication • protein localization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016224 (mRNA)
NP_057308 (protein)

XM_973143 (mRNA)
XP_978237 (protein)

Location

Chr 6: 158.16 - 158.29 Mb

Chr 17: 5.8 - 5.89 Mb

Pubmed search

[1]

[2]

Sorting nexin 9, also known as SNX9, is a human gene.^[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX9 sorting nexin 9.

[edit] Further reading

Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693–9. PMID 10531379.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546.
Lin Q, Lo CG, Cerione RA, Yang W (2002). "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.". J. Biol. Chem. 277 (12): 10134–8. doi:10.1074/jbc. M110329200. PMID 11799118.
Lundmark R, Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2.". Biochem. J. 362 (Pt 3): 597–607. PMID 11879186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lundmark R, Carlsson SR (2004). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.". J. Biol. Chem. 278 (47): 46772–81. doi:10.1074/jbc. M307334200. PMID 12952949.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions.". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc. M309909200. PMID 14679214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Lundmark R, Carlsson SR (2004). "Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.". J. Biol. Chem. 279 (41): 42694–702. doi:10.1074/jbc. M407430200. PMID 15299020.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Soulet F, Yarar D, Leonard M, Schmid SL (2005). "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.". Mol. Biol. Cell 16 (4): 2058–67. doi:10.1091/mbc. E04-11-1016. PMID 15703209.
Yeow-Fong L, Lim L, Manser E (2005). "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.". FEBS Lett. 579 (22): 5040–8. doi:10.1016/j.febslet.2005.07.093. PMID 16137687.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Childress C, Lin Q, Yang W (2006). "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.". Biochem. J. 394 (Pt 3): 693–8. doi:10.1042/BJ20050576. PMID 16316319.
Marchès O, Batchelor M, Shaw RK, et al. (2006). "EspF of enteropathogenic Escherichia coli binds sorting nexin 9.". J. Bacteriol. 188 (8): 3110–5. doi:10.1128/JB.188.8.3110-3115.2006. PMID 16585770.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMID 16903783.
Badour K, McGavin MK, Zhang J, et al. (2007). "Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.". Proc. Natl. Acad. Sci. U.S.A. 104 (5): 1593–8. doi:10.1073/pnas.0610543104. PMID 17242350.
Yarar D, Waterman-Storer CM, Schmid SL (2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.". Dev. Cell 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.