SNX4

From Wikipedia, the free encyclopedia

Sorting nexin 4

Identifiers

External IDs

OMIM: 605931 MGI: 1916400 HomoloGene: 36143

Gene ontology
Molecular Function:	• protein binding • phosphoinositide binding
Cellular Component:	• cytoplasm
Biological Process:	• endocytosis • cell communication • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003794 (mRNA)
NP_003785 (protein)

NM_080557 (mRNA)
NP_542124 (protein)

Location

Chr 3: 126.65 - 126.72 Mb

Chr 16: 33.17 - 33.22 Mb

Pubmed search

[1]

[2]

Sorting nexin 4, also known as SNX4, is a human gene.^[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX4 sorting nexin 4.

[edit] Further reading

Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.". Nat. Cell Biol. 9 (12): 1370-80. doi:10.1038/ncb1656. PMID 17994011.
Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.". Traffic 8 (3): 297-309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.". J. Cell. Sci. 116 (Pt 10): 1937-48. doi:10.1242/jcs.00403. PMID 12668730.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332-9. doi:10.1074/jbc.M100606200. PMID 11279102.
Haft CR, de la Luz Sierra M, Barr VA, et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors.". Mol. Cell. Biol. 18 (12): 7278-87. PMID 9819414.