SNX21

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Sorting nexin family member 21
Identifiers
Symbol(s) SNX21; C20orf161; MGC29895; PP3993; SNX-L; dJ337O18.4
External IDs MGI: 1917729 HomoloGene: 43132
Orthologs
Human Mouse
Entrez 90203 101113
Ensembl ENSG00000124104 ENSMUSG00000050373
Uniprot Q969T3 n/a
Refseq NM_001042632 (mRNA)
NP_001036097 (protein)		 NM_133924 (mRNA)
NP_598685 (protein)
Location Chr 20: 43.9 - 43.91 Mb Chr 2: 164.48 - 164.49 Mb
Pubmed search [1] [2]

Sorting nexin family member 21, also known as SNX21, is a human gene.[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SNX21 sorting nexin family member 21.

[edit] Further reading

  • Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins.". Nat. Rev. Mol. Cell Biol. 3 (12): 919-31. doi:10.1038/nrm974. PMID 12461558. 
  • Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling.". Biochem. J. 360 (Pt 3): 513-30. PMID 11736640. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zeng W, Yuan W, Wang Y, et al. (2003). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development.". Biochem. Biophys. Res. Commun. 299 (4): 542-8. PMID 12459172. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7-16. PMID 11485546. 
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