SNUPN

From Wikipedia, the free encyclopedia

Snurportin 1

PDB rendering based on 1xk5.

Available structures: 1xk5

Identifiers

Symbol(s)

SNUPN; KPNBL; RNUT1; Snurportin1

External IDs

OMIM: 607902 MGI: 1913319 HomoloGene: 4166

Gene ontology
Molecular Function:	• RNA cap binding • protein transporter activity
Cellular Component:	• nucleus • nuclear pore • cytoplasm
Biological Process:	• protein import into nucleus • transport • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042581 (mRNA)
NP_001036046 (protein)

NM_178374 (mRNA)
NP_848461 (protein)

Location

Chr 15: 73.68 - 73.71 Mb

Chr 9: 56.75 - 56.78 Mb

Pubmed search

[1]

[2]

Snurportin 1, also known as SNUPN, is a human gene.^[1]

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNUPN snurportin 1.

[edit] Further reading

Huber J, Cronshagen U, Kadokura M, et al. (1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMID 9670026.
Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm.". J. Cell Biol. 145 (2): 255–64. PMID 10209022.
Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.". Hum. Mol. Genet. 11 (15): 1785–95. PMID 12095920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.". EMBO J. 24 (13): 2235–43. doi:10.1038/sj.emboj.7600701. PMID 15920472.
Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains.". Mol. Biol. Cell 16 (10): 4660–71. doi:10.1091/mbc.E05-04-0316. PMID 16030253.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.