SNRP70

From Wikipedia, the free encyclopedia

Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)

Identifiers

SNRP70; RNPU1Z; RPU1; U170K; U1AP; U1RNP

External IDs

OMIM: 180740 MGI: 98341 HomoloGene: 20672

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• nucleus • spliceosome
Biological Process:	• nuclear mRNA splicing, via spliceosome • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001009820 (mRNA)
NP_001009820 (protein)

NM_009224 (mRNA)
NP_033250 (protein)

Location

Chr 19: 54.28 - 54.3 Mb

Chr 7: 45.24 - 45.26 Mb

Pubmed search

[1]

[2]

Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen), also known as SNRP70, is a human gene.^[1]

[edit] References

^ Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen).

[edit] Further reading

Wilk HE, Schaefer KP, Agris PF, et al. (1991). "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA.". Mol. Cell. Biochem. 106 (1): 55–66. PMID 1833625.
Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (1991). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3.". Genomics 8 (2): 371–9. PMID 2147422.
Spritz RA, Strunk K, Surowy CS, et al. (1988). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.". Nucleic Acids Res. 15 (24): 10373–91. PMID 2447561.
Query CC, Bentley RC, Keene JD (1989). "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.". Cell 57 (1): 89–101. PMID 2467746.
Du Clos TW (1989). "C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.". J. Immunol. 143 (8): 2553–9. PMID 2477447.
Theissen H, Etzerodt M, Reuter R, et al. (1987). "Cloning of the human cDNA for the U1 RNA-associated 70K protein.". EMBO J. 5 (12): 3209–17. PMID 3028775.
Romac JM, Graff DH, Keene JD (1994). "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.". Mol. Cell. Biol. 14 (7): 4662–70. PMID 7516470.
Wu JY, Maniatis T (1994). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.". Cell 75 (6): 1061–70. PMID 8261509.
Woppmann A, Will CL, Kornstädt U, et al. (1993). "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.". Nucleic Acids Res. 21 (12): 2815–22. PMID 8332490.
Northemann W, Berg H, Stahnke G, et al. (1996). "Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen.". Protein Expr. Purif. 6 (6): 748–56. doi:10.1006/prep.1995.0005. PMID 8746626.
Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.". Mol. Cell. Biol. 16 (10): 5400–8. PMID 8816452.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. PMID 9016565.
Klein Gunnewiek JM, van Aarssen Y, van der Kemp A, et al. (1997). "Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus.". Exp. Cell Res. 235 (1): 265–73. PMID 9281376.
Zhang WJ, Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.". Mol. Cell. Biol. 18 (2): 676–84. PMID 9447963.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing.". Genes Dev. 12 (7): 996–1009. PMID 9531537.
Cao W, Garcia-Blanco MA (1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.". J. Biol. Chem. 273 (32): 20629–35. PMID 9685421.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Xiao SH, Manley JL (1999). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMID 9799243.
Dumortier H, Klein Gunnewiek J, Roussel JP, et al. (1999). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle.". Nucleic Acids Res. 26 (23): 5486–91. PMID 9826776.