SNAI2

From Wikipedia, the free encyclopedia

Snail homolog 2 (Drosophila)

Identifiers

SNAI2; MGC10182; SLUG; SLUGH1; WS2D

External IDs

OMIM: 602150 MGI: 1096393 HomoloGene: 31127

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • multicellular organismal development • ectoderm and mesoderm interaction • sensory perception of sound • response to radiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003068 (mRNA)
NP_003059 (protein)

NM_011415 (mRNA)
NP_035545 (protein)

Location

Chr 8: 49.99 - 50 Mb

Chr 16: 14.62 - 14.62 Mb

Pubmed search

[1]

[2]

Snail homolog 2 (Drosophila), also known as SNAI2 or Slug, is a human gene.^[1]

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNAI2 snail homolog 2 (Drosophila).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Savagner P, Yamada KM, Thiery JP (1997). "The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.". J. Cell Biol. 137 (6): 1403-19. PMID 9182671.
Rhim H, Savagner P, Thibaudeau G, et al. (1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8.". Mamm. Genome 8 (11): 872-3. PMID 9337409.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Cohen ME, Yin M, Paznekas WA, et al. (1998). "Human SLUG gene organization, expression, and chromosome map location on 8q.". Genomics 51 (3): 468-71. doi:10.1006/geno.1998.5367. PMID 9721220.
Stegmann K, Boecker J, Kosan C, et al. (1999). "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.". Mutat. Res. 406 (2-4): 63-9. PMID 10479723.
Inukai T, Inoue A, Kurosawa H, et al. (1999). "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.". Mol. Cell 4 (3): 343-52. PMID 10518215.
Hemavathy K, Guru SC, Harris J, et al. (2000). "Human Slug is a repressor that localizes to sites of active transcription.". Mol. Cell. Biol. 20 (14): 5087-95. PMID 10866665.
Hajra KM, Chen DY, Fearon ER (2002). "The SLUG zinc-finger protein represses E-cadherin in breast cancer.". Cancer Res. 62 (6): 1613-8. PMID 11912130.
Sánchez-Martín M, Rodríguez-García A, Pérez-Losada J, et al. (2003). "SLUG (SNAI2) deletions in patients with Waardenburg disease.". Hum. Mol. Genet. 11 (25): 3231-6. PMID 12444107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kajita M, McClinic KN, Wade PA (2004). "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.". Mol. Cell. Biol. 24 (17): 7559-66. doi:10.1128/MCB.24.17.7559-7566.2004. PMID 15314165.
Catalano A, Rodilossi S, Rippo MR, et al. (2004). "Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.". J. Biol. Chem. 279 (45): 46706-14. doi:10.1074/jbc.M406696200. PMID 15337769.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Uchikado Y, Natsugoe S, Okumura H, et al. (2005). "Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma.". Clin. Cancer Res. 11 (3): 1174-80. PMID 15709186.
Tripathi MK, Misra S, Khedkar SV, et al. (2005). "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.". J. Biol. Chem. 280 (17): 17163-71. doi:10.1074/jbc.M501375200. PMID 15734731.
Tripathi MK, Misra S, Chaudhuri G (2005). "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.". Biochem. Biophys. Res. Commun. 329 (2): 508-15. doi:10.1016/j.bbrc.2005.02.006. PMID 15737616.
Moody SE, Perez D, Pan TC, et al. (2005). "The transcriptional repressor Snail promotes mammary tumor recurrence.". Cancer Cell 8 (3): 197-209. doi:10.1016/j.ccr.2005.07.009. PMID 16169465.
Chen M, Chen LM, Chai KX (2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.". Prostate 66 (9): 911-20. doi:10.1002/pros.20325. PMID 16541421.
Turner FE, Broad S, Khanim FL, et al. (2006). "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes.". J. Biol. Chem. 281 (30): 21321-31. doi:10.1074/jbc.M509731200. PMID 16707493.