SMUG1

From Wikipedia, the free encyclopedia

Single-strand-selective monofunctional uracil-DNA glycosylase 1

Identifiers

SMUG1; FDG; HMUDG; MGC104370; UNG3

External IDs

OMIM: 607753 MGI: 1918976 HomoloGene: 8629

Gene ontology
Molecular Function:	• DNA binding • single-stranded DNA binding • protein binding • hydrolase activity, acting on glycosyl bonds • single-strand selective uracil DNA N-glycosylase activity
Cellular Component:	• nucleus • nucleolus
Biological Process:	• base-excision repair • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014311 (mRNA)
NP_055126 (protein)

XM_001004064 (mRNA)
XP_001004064 (protein)

Location

Chr 12: 52.86 - 52.87 Mb

Chr 15: 102.98 - 102.99 Mb

Pubmed search

[1]

[2]

Single-strand-selective monofunctional uracil-DNA glycosylase 1, also known as SMUG1, is a human gene.^[1]

SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL (1999). "Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.". Curr. Biol. 9 (4): 174–85. PMID 10074426.
Boorstein RJ, Cummings A, Marenstein DR, et al. (2001). "Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.". J. Biol. Chem. 276 (45): 41991–7. doi:10.1074/jbc.M106953200. PMID 11526119.
Kavli B, Sundheim O, Akbari M, et al. (2002). "hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.". J. Biol. Chem. 277 (42): 39926–36. doi:10.1074/jbc.M207107200. PMID 12161446.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Masaoka A, Matsubara M, Hasegawa R, et al. (2003). "Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.". Biochemistry 42 (17): 5003–12. doi:10.1021/bi0273213. PMID 12718543.
Wibley JE, Waters TR, Haushalter K, et al. (2003). "Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.". Mol. Cell 11 (6): 1647–59. PMID 12820976.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Matsubara M, Tanaka T, Terato H, et al. (2004). "Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.". Nucleic Acids Res. 32 (17): 5291–302. doi:10.1093/nar/gkh859. PMID 15466595.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Schröfelbauer B, Yu Q, Zeitlin SG, Landau NR (2005). "Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases.". J. Virol. 79 (17): 10978–87. doi:10.1128/JVI.79.17.10978-10987.2005. PMID 16103149.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Di Noia JM, Rada C, Neuberger MS (2006). "SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.". EMBO J. 25 (3): 585–95. doi:10.1038/sj.emboj.7600939. PMID 16407970.
Broderick P, Bagratuni T, Vijayakrishnan J, et al. (2006). "Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.". BMC Cancer 6: 243. doi:10.1186/1471-2407-6-243. PMID 17029639.
Matsubara M, Tanaka T, Terato H, Ide H (2007). "Action mechanism of human SMUG1 uracil-DNA glycosylase.". Nucleic Acids Symp Ser (Oxf) (49): 295–6. doi:10.1093/nass/49.1.295. PMID 17150750.
Pettersen HS, Sundheim O, Gilljam KM, et al. (2007). "Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.". Nucleic Acids Res. 35 (12): 3879–92. doi:10.1093/nar/gkm372. PMID 17537817.