Small nucleolar RNA snoR9 plant

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Small nucleolar RNA snoR9

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Moxon SJ, Daub J
Seed alignment:	Moxon SJ

snoR9 is a non-coding RNA (ncRNA) which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

R9 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs ^[1].

This plant snoRNA was identified in Arabidopsis thaliana by computational screening and experimentally verified by primer extension analysis^[2] This snoRNA is not related to the snoRNA identified in hyperthermophiles also called snoR9.

[edit] References

^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol. Cell. Biol. 22 (19): 6663–8. PMID 12215523.
^ Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID 11469857.