Small nucleolar RNA SNORD60

From Wikipedia, the free encyclopedia

This article or section contains too much jargon and may need simplification or further explanation.
Please discuss this issue on the talk page, and/or remove or explain jargon terms used in the article. Editing help is available.
This article has been tagged since June 2007.

Small nucleolar RNA SNORD60

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Moxon SJ
Seed alignment:	Moxon SJ
Avg length:	81.7 nucleotides
Avg identity:	87%

This small nucleolar RNA (snoRNA) SNORD60 (also known as U60) is the functional product of a gene but is nottranslated into a protein. Non protein coding RNA molecules usually contain important secondary structure or ligand binding motifs and are involved in many important biological processes in the cell.

U60 belongs to the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1].

[edit] References

[1] Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
[2] Kiss-Laszlo, Z; Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85: 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.