Small nuclear ribonucleoprotein D2

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Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
PDB rendering based on 1b34.
Available structures: 1b34
Identifiers
Symbol(s) SNRPD2; SNRPD1; SMD2
External IDs OMIM: 601061 MGI: 98345 HomoloGene: 3381
Orthologs
Human Mouse
Entrez 6633 107686
Ensembl n/a ENSMUSG00000040824
Uniprot n/a Q14AF6
Refseq NM_004597 (mRNA)
NP_004588 (protein)		 NM_026943 (mRNA)
NP_081219 (protein)
Location n/a Chr 7: 18.31 - 18.31 Mb
Pubmed search [1] [2]

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa, also known as SNRPD2, is a human gene.[1]

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa.

[edit] Further reading

  • Lehmeier T, Foulaki K, Lührmann R (1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5.". Nucleic Acids Res. 18 (22): 6475–84. PMID 1701240. 
  • Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen.". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. PMID 3260384. 
  • Lehmeier T, Raker V, Hermann H, Lührmann R (1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12317–21. PMID 7527560. 
  • Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013–21. PMID 9323129. 
  • Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867. 
  • Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.". Cell 96 (3): 375–87. PMID 10025403. 
  • Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. PMID 10601333. 
  • Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. PMID 10725331. 
  • Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins.". Hum. Mol. Genet. 9 (13): 1977–86. PMID 10942426. 
  • Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMID 11101529. 
  • Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins.". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666. 
  • Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1-2): 187–96. doi:10.1093/emboj/20.1.187. PMID 11226169. 
  • Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716. 
  • Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230. 
  • Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins.". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452. 
  • Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. 
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638. 
  • Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067. 
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