SMARCE1

From Wikipedia, the free encyclopedia

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Identifiers

External IDs

OMIM: 603111 MGI: 1927347 HomoloGene: 37727

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • transcription coactivator activity • protein binding • N-acetyltransferase activity
Cellular Component:	• nuclear chromosome • nucleus • transcriptional repressor complex
Biological Process:	• nucleosome disassembly • regulation of transcription from RNA polymerase II promoter • chromatin modification • negative regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003079 (mRNA)
NP_003070 (protein)

NM_020618 (mRNA)
NP_065643 (protein)

Location

n/a

Chr 11: 99.03 - 99.05 Mb

Pubmed search

[1]

[2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, also known as SMARCE1, is a human gene.^[1]

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1.

[edit] Further reading

Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes.". Curr. Opin. Genet. Dev. 13 (2): 136–42. PMID 12672490.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.". EMBO J. 15 (19): 5370–82. PMID 8895581.
Wang W, Chi T, Xue Y, et al. (1998). "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 492–8. PMID 9435219.
Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.". Mol. Cell 3 (2): 247–53. PMID 10078207.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMID 11078522.
Decristofaro MF, Betz BL, Rorie CJ, et al. (2001). "Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies.". J. Cell. Physiol. 186 (1): 136–45. doi:10.1002/1097-4652(200101)186:1<136::AID-JCP1010>3.0.CO;2-4. PMID 11147808.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Chi TH, Wan M, Zhao K, et al. (2002). "Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.". Nature 418 (6894): 195–9. doi:10.1038/nature00876. PMID 12110891.
Belandia B, Orford RL, Hurst HC, Parker MG (2002). "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes.". EMBO J. 21 (15): 4094–103. PMID 12145209.
Battaglioli E, Andrés ME, Rose DW, et al. (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex.". J. Biol. Chem. 277 (43): 41038–45. doi:10.1074/jbc.M205691200. PMID 12192000.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Baker KM, Wei G, Schaffner AE, Ostrowski MC (2003). "Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.". J. Biol. Chem. 278 (20): 17876–84. doi:10.1074/jbc.M209480200. PMID 12637547.
Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.". Cell 113 (7): 905–17. PMID 12837248.
Hsiao PW, Fryer CJ, Trotter KW, et al. (2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.". Mol. Cell. Biol. 23 (17): 6210–20. PMID 12917342.
Wu K, Bottazzi ME, de la Fuente C, et al. (2004). "Protein profile of tax-associated complexes.". J. Biol. Chem. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function.". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. PMID 14623284.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.