SMARCD3

From Wikipedia, the free encyclopedia

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

Identifiers

SMARCD3; Rsc6p; BAF60C; CRACD3; MGC111010

External IDs

OMIM: 601737 MGI: 1914243 HomoloGene: 2314

Gene ontology
Molecular Function:	• transcription coactivator activity • receptor binding • transcription factor binding • transcription regulator activity • nuclear hormone receptor binding
Cellular Component:	• nucleus • nucleoplasm • SWI/SNF complex
Biological Process:	• chromatin remodeling • transcription • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001003801 (mRNA)
NP_001003801 (protein)

NM_025891 (mRNA)
NP_080167 (protein)

Location

Chr 7: 150.57 - 150.6 Mb

Chr 5: 24.1 - 24.11 Mb

Pubmed search

[1]

[2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, also known as SMARCD3, is a human gene.^[1]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3.

[edit] Further reading

Wang W, Xue Y, Zhou S, et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes.". Genes Dev. 10 (17): 2117-30. PMID 8804307.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.". EMBO J. 15 (19): 5370-82. PMID 8895581.
Ring HZ, Vameghi-Meyers V, Wang W, et al. (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.". Genomics 51 (1): 140-3. doi:10.1006/geno.1998.5343. PMID 9693044.
Shanahan F, Seghezzi W, Parry D, et al. (1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.". Mol. Cell. Biol. 19 (2): 1460-9. PMID 9891079.
Barker N, Hurlstone A, Musisi H, et al. (2001). "The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.". EMBO J. 20 (17): 4935-43. doi:10.1093/emboj/20.17.4935. PMID 11532957.
Otsuki T, Furukawa Y, Ikeda K, et al. (2002). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.". Hum. Mol. Genet. 10 (23): 2651-60. PMID 11726552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.". Biochem. Biophys. Res. Commun. 313 (3): 654-65. PMID 14697242.
Debril MB, Gelman L, Fayard E, et al. (2004). "Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.". J. Biol. Chem. 279 (16): 16677-86. doi:10.1074/jbc.M312288200. PMID 14701856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mahmoudi T, Parra M, Vries RG, et al. (2006). "The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.". J. Biol. Chem. 281 (29): 19960-8. doi:10.1074/jbc.M603336200. PMID 16687403.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.