SMARCD2

From Wikipedia, the free encyclopedia

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

Identifiers

SMARCD2; Rsc6p; BAF60B; CRACD2; PRO2451

External IDs

OMIM: 601736 MGI: 1933621 HomoloGene: 20671

Gene ontology
Molecular Function:	• transcription coactivator activity • protein binding
Cellular Component:	• nucleus • nucleoplasm
Biological Process:	• chromatin remodeling • transcription • regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003077 (mRNA)
NP_003068 (protein)

NM_031878 (mRNA)
NP_114084 (protein)

Location

Chr 17: 59.26 - 59.27 Mb

n/a

Pubmed search

[1]

[2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, also known as SMARCD2, is a human gene.^[1]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2.

[edit] Further reading

Wang W, Xue Y, Zhou S, et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes.". Genes Dev. 10 (17): 2117–30. PMID 8804307.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.". EMBO J. 15 (19): 5370–82. PMID 8895581.
Ring HZ, Vameghi-Meyers V, Wang W, et al. (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.". Genomics 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
Surabhi RM, Daly LD, Cattini PA (1999). "Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17.". Genome 42 (3): 545–9. PMID 10382302.
Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.". Cell 102 (2): 257–65. PMID 10943845.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.". Mol. Cell. Biol. 23 (8): 2942–52. PMID 12665591.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.