SMARCA4

From Wikipedia, the free encyclopedia


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
PDB rendering based on 2grc.
Available structures: 2grc, 2h60
Identifiers
Symbol(s) SMARCA4; SNF2LB; SWI2; BAF190; SNF2; BRG1; FLJ39786; SNF2-BETA; SNF2L4; hSNF2b
External IDs OMIM: 603254 MGI: 88192 HomoloGene: 55712
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6597 20586
Ensembl ENSG00000127616 ENSMUSG00000032187
Uniprot P51532 n/a
Refseq NM_003072 (mRNA)
NP_003063 (protein)		 NM_011417 (mRNA)
NP_035547 (protein)
Location Chr 19: 10.93 - 11.03 Mb Chr 9: 21.37 - 21.45 Mb
Pubmed search [1] [2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, also known as SMARCA4, is a human gene.

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44.[1] Recently a high percent of inactivation of this gene has been found in human lung cancer cell lines (2).

[edit] References

  1. ^ Entrez Gene: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4.

(2) Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat. 2008 Apr 3;

[edit] Further reading

Involvement of the Chromatin-Remodeling Factor BRG1/SMARCA4 in Human Cancer. Epigenetics. 2008 Apr 17;3(2)

  • Voellmy R (1996). "Sensing stress and responding to stress.". EXS 77: 121–37. PMID 8856972. 
  • Peterson CL (2002). "Chromatin remodeling: nucleosomes bulging at the seams.". Curr. Biol. 12 (7): R245–7. PMID 11937040.