SLU7

From Wikipedia, the free encyclopedia

SLU7 splicing factor homolog (S. cerevisiae)

Identifiers

SLU7; 9G8; MGC9280; hSlu7

External IDs

OMIM: 605974 MGI: 2385598 HomoloGene: 4690

Gene ontology
Molecular Function:	• second spliceosomal transesterification activity • nucleic acid binding • zinc ion binding • pre-mRNA 3'-splice site binding
Cellular Component:	• spliceosome • nuclear speck • small nuclear ribonucleoprotein complex
Biological Process:	• alternative nuclear mRNA splicing, via spliceosome • nuclear mRNA 3'-splice site recognition

Orthologs

Human

Mouse

Refseq

NM_006425 (mRNA)
NP_006416 (protein)

NM_148673 (mRNA)
NP_683514 (protein)

Location

Chr 5: 159.76 - 159.78 Mb

Chr 11: 43.28 - 43.29 Mb

Pubmed search

[1]

[2]

SLU7 splicing factor homolog (S. cerevisiae), also known as SLU7, is a human gene.^[1]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.^[1]

[edit] References

^ ^a ^b Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae).

[edit] Further reading

Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing.". RNA 13 (11): 1988–99. doi:10.1261/rna.492907. PMID 17804646.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Shomron N, Alberstein M, Reznik M, Ast G (2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing.". J. Cell. Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus.". Mol. Biol. Cell 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMID 15181151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing.". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMID 11238888.
Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice.". Nature 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016.
Chua K, Reed R (1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing.". Genes Dev. 13 (7): 841–50. PMID 10197984.