SLITRK2

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SLIT and NTRK-like family, member 2
Identifiers
Symbol(s) SLITRK2; CXorf2; DKFZp451E1911; KIAA1854; MGC129912; MGC129913; SLITL1
External IDs OMIM: 300561 MGI: 2679449 HomoloGene: 13054
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84631 245450
Ensembl ENSG00000185985 ENSMUSG00000036790
Uniprot Q9H156 Q14DP8
Refseq NM_032539 (mRNA)
NP_115928 (protein)		 XM_205324 (mRNA)
XP_205324 (protein)
Location Chr X: 144.71 - 144.72 Mb Chr X: 62.91 - 62.92 Mb
Pubmed search [1] [2]

SLIT and NTRK-like family, member 2, also known as SLITRK2, is a human gene.[1]

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2.

[edit] Further reading

  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Aruga J, Yokota N, Mikoshiba K (2004). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.". Gene 315: 87-94. PMID 14557068. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85-95. PMID 11347906. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
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