SLITRK1 (gene)

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SLIT and NTRK-like family, member 1
Identifiers
Symbol(s) SLITRK1; KIAA0918; KIAA1910; LRRC12; RP11-395N17.1
External IDs OMIM: 609678 MGI: 2679446 HomoloGene: 14174
Orthologs
Human Mouse
Entrez 114798 76965
Ensembl ENSG00000178235 ENSMUSG00000075478
Uniprot Q96PX8 Q69Z70
Refseq NM_052910 (mRNA)
NP_443142 (protein)		 NM_199065 (mRNA)
NP_951020 (protein)
Location Chr 13: 83.35 - 83.35 Mb Chr 14: 107.79 - 107.8 Mb
Pubmed search [1] [2]

SLIT and NTRK-like family, member 1, also known as SLITRK1, is a human gene.[1]

Members of the SLITRK family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SLITRK1 SLIT and NTRK-like family, member 1.

[edit] Further reading

  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179-87. PMID 11572484. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Aruga J, Mikoshiba K (2004). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.". Mol. Cell. Neurosci. 24 (1): 117-29. PMID 14550773. 
  • Aruga J, Yokota N, Mikoshiba K (2004). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.". Gene 315: 87-94. PMID 14557068. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Abelson JF, Kwan KY, O'Roak BJ, et al. (2005). "Sequence variants in SLITRK1 are associated with Tourette's syndrome.". Science 310 (5746): 317-20. doi:10.1126/science.1116502. PMID 16224024. 
  • Burton A (2006). "SLITRK1 trouble in Tourette's syndrome.". Lancet neurology 4 (12): 801. PMID 16323357. 
  • Wendland JR, Kruse MR, Murphy DL (2006). "Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder.". Mol. Psychiatry 11 (9): 802-4. doi:10.1038/sj.mp.4001848. PMID 16936762. 
  • Zuchner S, Cuccaro ML, Tran-Viet KN, et al. (2006). "SLITRK1 mutations in trichotillomania.". Mol. Psychiatry 11 (10): 887-9. doi:10.1038/sj.mp.4001865. PMID 17003809. 
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