SLC6A14

From Wikipedia, the free encyclopedia

Solute carrier family 6 (amino acid transporter), member 14

Identifiers

External IDs

OMIM: 300444 MGI: 1890216 HomoloGene: 38290

Gene ontology
Molecular Function:	• neurotransmitter:sodium symporter activity • amino acid transmembrane transporter activity • symporter activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• amino acid metabolic process • neurotransmitter transport • amino acid transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007231 (mRNA)
NP_009162 (protein)

NM_020049 (mRNA)
NP_064433 (protein)

Location

Chr X: 115.48 - 115.51 Mb

Chr X: 20.87 - 20.9 Mb

Pubmed search

[1]

[2]

Solute carrier family 6 (amino acid transporter), member 14, also known as SLC6A14, is a human gene.^[1]

SLC6A14 is a member of the Na(+)- and Cl(-)-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na(+)- and Cl(-)-dependent manner.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14.

[edit] Further reading

Sloan JL, Mager S (1999). "Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).". J. Biol. Chem. 274 (34): 23740-5. PMID 10446133.
Ohman M, Oksanen L, Kaprio J, et al. (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24.". J. Clin. Endocrinol. Metab. 85 (9): 3183-90. PMID 10999806.
Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39-49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suviolahti E, Oksanen LJ, Ohman M, et al. (2004). "The SLC6A14 gene shows evidence of association with obesity.". J. Clin. Invest. 112 (11): 1762-72. doi:10.1172/JCI200317491. PMID 14660752.
Durand E, Boutin P, Meyre D, et al. (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians.". Diabetes 53 (9): 2483-6. PMID 15331564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Gupta N, Miyauchi S, Martindale RG, et al. (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.". Biochim. Biophys. Acta 1741 (1-2): 215-23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.