SLC35C2

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Solute carrier family 35, member C2
Identifiers
Symbol(s) SLC35C2; BA394O2.1; C20orf5; CGI-15; FLJ37039; MGC20633; MGC32079; MGC39183; OVCOV1
External IDs MGI: 2385166 HomoloGene: 6581
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51006 228875
Ensembl ENSG00000080189 ENSMUSG00000017664
Uniprot Q9NQQ7 Q3U226
Refseq NM_015945 (mRNA)
NP_057029 (protein)		 NM_144893 (mRNA)
NP_659142 (protein)
Location Chr 20: 44.41 - 44.43 Mb Chr 2: 164.97 - 164.98 Mb
Pubmed search [1] [2]

Solute carrier family 35, member C2, also known as SLC35C2, is a human gene.[1]

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SLC35C2 solute carrier family 35, member C2.

[edit] Further reading

  • Lash GE, Postovit LM, Matthews NE, et al. (2002). "Oxygen as a regulator of cellular phenotypes in pregnancy and cancer.". Can. J. Physiol. Pharmacol. 80 (2): 103-9. PMID 11934252. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093. 
  • Pires Martins R, Leach RE, Krawetz SA (2001). "Whole-body gene expression by data mining.". Genomics 72 (1): 34-42. doi:10.1006/geno.2000.6437. PMID 11247664. 
  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45-57. doi:10.1006/geno.2001.6584. PMID 11549316. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Leach R, Duniec-Dmuchowski Z, Tanaka T, et al. (2002). "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 94 (3-4): 252-3. PMID 11856893. 
  • Leach RE, Duniec-Dmuchowski ZM, Pesole G, et al. (2003). "Identification, molecular characterization, and tissue expression of OVCOV1.". Mamm. Genome 13 (11): 619-24. doi:10.1007/s00335-002-2185-4. PMID 12461647. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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