SLC27A5

From Wikipedia, the free encyclopedia

Solute carrier family 27 (fatty acid transporter), member 5

Identifiers

SLC27A5; ACSB; ACSVL6; FACVL3; FATP5; FLJ22987; VLACSR; VLCS-H2; VLCSH2

External IDs

OMIM: 603314 MGI: 1347100 HomoloGene: 7596

Gene ontology
Molecular Function:	• nucleotide binding • long-chain-fatty-acid-CoA ligase activity • ligase activity • cholate-CoA ligase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• very-long-chain fatty acid metabolic process • lipid metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012254 (mRNA)
NP_036386 (protein)

NM_009512 (mRNA)
NP_033538 (protein)

Location

Chr 19: 63.7 - 63.72 Mb

Chr 7: 11.89 - 11.9 Mb

Pubmed search

[1]

[2]

Solute carrier family 27 (fatty acid transporter), member 5, also known as SLC27A5, is a human gene.^[1]

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.^[1]

[edit] References

^ ^a ^b Entrez Gene: SLC27A5 solute carrier family 27 (fatty acid transporter), member 5.

[edit] Further reading

Fisher E, Nitz I, Lindner I, et al. (2007). "Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation.". Mol Nutr Food Res 51 (2): 185-91. doi:10.1002/mnfr.200600162. PMID 17266179.
Tu N, Hu Y, Mivechi NF (2006). "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins.". J. Cell. Biochem. 98 (6): 1528-42. doi:10.1002/jcb.20865. PMID 16552721.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mihalik SJ, Steinberg SJ, Pei Z, et al. (2002). "Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.". J. Biol. Chem. 277 (27): 24771-9. doi:10.1074/jbc.M203295200. PMID 11980911.
Steinberg SJ, Mihalik SJ, Kim DG, et al. (2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase.". J. Biol. Chem. 275 (21): 15605-8. doi:10.1074/jbc.C000015200. PMID 10749848.
Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein.". Mol. Genet. Metab. 68 (1): 32-42. doi:10.1006/mgme.1999.2883. PMID 10479480.
Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein.". Prostaglandins Leukot. Essent. Fatty Acids 60 (5-6): 323-8. PMID 10471116.
Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625-9. PMID 9671728.
Berger J, Truppe C, Neumann H, Forss-Petter S (1998). "A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern.". Biochem. Biophys. Res. Commun. 247 (2): 255-60. doi:10.1006/bbrc.1998.8770. PMID 9642112.