SIRT7

From Wikipedia, the free encyclopedia

Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)

Identifiers

SIRT7; MGC126840; MGC126842; SIR2L7

External IDs

OMIM: 606212 MGI: 2385849 HomoloGene: 56152

Gene ontology
Molecular Function:	• DNA binding • pyrroline-5-carboxylate reductase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular Component:	• chromatin silencing complex
Biological Process:	• electron transport • chromatin silencing • regulation of transcription, DNA-dependent • proline biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016538 (mRNA)
NP_057622 (protein)

NM_153056 (mRNA)
NP_694696 (protein)

Location

Chr 17: 77.46 - 77.47 Mb

Chr 11: 120.43 - 120.44 Mb

Pubmed search

[1]

[2]

Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae), also known as SIRT7, is a human gene.^[1]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.^[1]

[edit] References

^ ^a ^b Entrez Gene: SIRT7 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae).

[edit] Further reading

Frye RA (2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.". Biochem. Biophys. Res. Commun. 273 (2): 793–8. doi:10.1006/bbrc.2000.3000. PMID 10873683.
de Nigris F, Cerutti J, Morelli C, et al. (2002). "Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.". Br. J. Cancer 86 (6): 917–23. doi:10.1038/sj.bjc.6600156. PMID 11953824.
De Nigris F, Cerutti J, Morelli C, et al. (2003). "Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.". Br. J. Cancer 87 (12): 1479. doi:10.1038/sj.bjc.6600636. PMID 12454780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Voelter-Mahlknecht S, Letzel S, Mahlknecht U (2006). "Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.". Int. J. Oncol. 28 (4): 899–908. PMID 16525639.
Ford E, Voit R, Liszt G, et al. (2006). "Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.". Genes Dev. 20 (9): 1075–80. doi:10.1101/gad.1399706. PMID 16618798.
Ashraf N, Zino S, Macintyre A, et al. (2006). "Altered sirtuin expression is associated with node-positive breast cancer.". Br. J. Cancer 95 (8): 1056–61. doi:10.1038/sj.bjc.6603384. PMID 17003781.