SIRT5

From Wikipedia, the free encyclopedia

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)

PDB rendering based on 2b4y.

Available structures: 2b4y, 2nyr

Identifiers

Symbol(s)

SIRT5; SIR2L5

External IDs

OMIM: 604483 MGI: 1915596 HomoloGene: 40825

Gene ontology
Molecular Function:	• DNA binding • NAD+ ADP-ribosyltransferase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular Component:	• chromatin silencing complex
Biological Process:	• chromatin silencing • regulation of transcription, DNA-dependent • protein amino acid ADP-ribosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012241 (mRNA)
NP_036373 (protein)

NM_178848 (mRNA)
NP_849179 (protein)

Location

Chr 6: 13.68 - 13.72 Mb

Chr 13: 43.38 - 43.41 Mb

Pubmed search

[1]

[2]

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5, is a human gene.^[1]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae).

[edit] Further reading

Frye RA (1999). "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.". Biochem. Biophys. Res. Commun. 260 (1): 273-9. doi:10.1006/bbrc.1999.0897. PMID 10381378.
Frye RA (2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.". Biochem. Biophys. Res. Commun. 273 (2): 793-8. doi:10.1006/bbrc.2000.3000. PMID 10873683.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Mahlknecht U, Ho AD, Letzel S, Voelter-Mahlknecht S (2006). "Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization.". Cytogenet. Genome Res. 112 (3-4): 208-12. doi:10.1159/000089872. PMID 16484774.
Chowdari KV, Northup A, Pless L, et al. (2007). "DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia.". Genes Brain Behav. 6 (3): 229-39. doi:10.1111/j.1601-183X.2006.00251.x. PMID 16827919.