SIPA1

From Wikipedia, the free encyclopedia

Signal-induced proliferation-associated gene 1

Identifiers

SIPA1; MGC102688; MGC17037; SPA1

External IDs

OMIM: 602180 MGI: 107576 HomoloGene: 7940

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding • Rap GTPase activator activity
Cellular Component:	• intracellular • nucleus • membrane
Biological Process:	• induction of apoptosis • cytoskeleton organization and biogenesis • negative regulation of cell adhesion • intracellular signaling cascade • cell proliferation • negative regulation of cell growth • negative regulation of progression through cell cycle • regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006747 (mRNA)
NP_006738 (protein)

NM_011379 (mRNA)
NP_035509 (protein)

Location

n/a

Chr 19: 5.65 - 5.66 Mb

Pubmed search

[1]

[2]

Signal-induced proliferation-associated gene 1, also known as SIPA1, is a human gene.^[1]

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.^[1]

[edit] References

^ ^a ^b Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1.

[edit] Further reading

Minato N (1997). "[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]". Hum. Cell 9 (1): 11-6. PMID 9183624.
Hattori M, Tsukamoto N, Nur-e-Kamal MS, et al. (1995). "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.". Mol. Cell. Biol. 15 (1): 552-60. PMID 7799964.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Wada Y, Kubota H, Maeda M, et al. (1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human.". Genomics 39 (1): 66-73. doi:10.1006/geno.1996.4464. PMID 9027487.
Kurachi H, Wada Y, Tsukamoto N, et al. (1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product.". J. Biol. Chem. 272 (44): 28081-8. PMID 9346962.
Ebrahimi S, Wang E, Udar N, et al. (1998). "Genomic organization and cloning of the human homologue of murine Sipa-1.". Gene 214 (1-2): 215-21. PMID 9651531.
Tsukamoto N, Hattori M, Yang H, et al. (1999). "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion.". J. Biol. Chem. 274 (26): 18463-9. PMID 10373454.
Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis.". J. Biol. Chem. 276 (41): 38173-8. doi:10.1074/jbc.M103140200. PMID 11461903.
Roy BC, Kohu K, Matsuura K, et al. (2003). "SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus.". Genes Cells 7 (6): 607-17. PMID 12059963.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization.". Mol. Cell. Biol. 24 (20): 9059-69. doi:10.1128/MCB.24.20.9059-9069.2004. PMID 15456879.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Crawford NP, Ziogas A, Peel DJ, et al. (2006). "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.". Breast Cancer Res. 8 (2): R16. doi:10.1186/bcr1389. PMID 16563182.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.