SILV

From Wikipedia, the free encyclopedia

Silver homolog (mouse)

Identifiers

SILV; SI; D12S53E; ME20; PMEL17; SIL; gp100

External IDs

OMIM: 155550 MGI: 98301 HomoloGene: 5048

Gene ontology
Cellular Component:	• extracellular region • extracellular space • plasma membrane • integral to membrane
Biological Process:	• melanin biosynthetic process from tyrosine

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006928 (mRNA)
NP_008859 (protein)

NM_021882 (mRNA)
NP_068682 (protein)

Location

Chr 12: 54.63 - 54.65 Mb

Chr 10: 128.11 - 128.12 Mb

Pubmed search

[1]

[2]

Silver homolog (mouse), also known as SILV, is a human gene.^[1]

[edit] References

^ Entrez Gene: SILV silver homolog (mouse).

[edit] Further reading

Aplan PD, Lombardi DP, Kirsch IR (1991). "Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.". Mol. Cell. Biol. 11 (11): 5462–9. PMID 1922059.
Kwon BS, Chintamaneni C, Kozak CA, et al. (1991). "A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9228–32. PMID 1924386.
Brown L, Cheng JT, Chen Q, et al. (1990). "Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.". EMBO J. 9 (10): 3343–51. PMID 2209547.
Aplan PD, Lombardi DP, Ginsberg AM, et al. (1991). "Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.". Science 250 (4986): 1426–9. PMID 2255914.
Adema GJ, de Boer AJ, Vogel AM, et al. (1994). "Molecular characterization of the melanocyte lineage-specific antigen gp100.". J. Biol. Chem. 269 (31): 20126–33. PMID 7519602.
Kawakami Y, Eliyahu S, Delgado CH, et al. (1994). "Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6458–62. PMID 8022805.
Maresh GA, Marken JS, Neubauer M, et al. (1994). "Cloning and expression of the gene for the melanoma-associated ME20 antigen.". DNA Cell Biol. 13 (2): 87–95. PMID 8179825.
Bailin T, Lee ST, Spritz RA (1996). "Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus.". J. Invest. Dermatol. 106 (1): 24–7. PMID 8592076.
Chakraborty AK, Platt JT, Kim KK, et al. (1996). "Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.". Eur. J. Biochem. 236 (1): 180–8. PMID 8617263.
Kim KK, Youn BS, Heng HH, et al. (1996). "Genomic organization and FISH mapping of human Pmel 17, the putative silver locus.". Pigment Cell Res. 9 (1): 42–8. PMID 8739560.
Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.". Am. J. Pathol. 150 (6): 2143–52. PMID 9176405.
Wagner SN, Wagner C, Schultewolter T, Goos M (1997). "Analysis of Pmel17/gp100 expression in primary human tissue specimens: implications for melanoma immuno- and gene-therapy.". Cancer Immunol. Immunother. 44 (4): 239–47. PMID 9222283.
Curry BJ, Myers K, Hersey P (1998). "Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.". J. Clin. Oncol. 16 (5): 1760–9. PMID 9586889.
Lupetti R, Pisarra P, Verrecchia A, et al. (1998). "Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage.". J. Exp. Med. 188 (6): 1005–16. PMID 9743519.
Lukowsky A, Bellmann B, Ringk A, et al. (1999). "Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.". J. Invest. Dermatol. 113 (4): 554–9. doi:10.1046/j.1523-1747.1999.00719.x. PMID 10504440.
Raposo G, Tenza D, Murphy DM, et al. (2001). "Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells.". J. Cell Biol. 152 (4): 809–24. PMID 11266471.
Virador V, Matsunaga N, Matsunaga J, et al. (2002). "Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions.". Pigment Cell Res. 14 (4): 289–97. PMID 11549113.
Berson JF, Harper DC, Tenza D, et al. (2002). "Pmel17 initiates premelanosome morphogenesis within multivesicular bodies.". Mol. Biol. Cell 12 (11): 3451–64. PMID 11694580.
Sensi M, Pellegatta S, Vegetti C, et al. (2003). "Identification of a novel gp100/pMel17 peptide presented by HLA-A*6801 and recognized on human melanoma by cytolytic T cell clones.". Tissue Antigens 59 (4): 273–9. PMID 12135425.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.