Sialate O-acetylesterase

From Wikipedia, the free encyclopedia

In enzymology, a sialate O-acetylesterase (EC 3.1.1.53) is an enzyme that catalyzes the chemical reaction

N-acetyl-O-acetylneuraminate + H₂O N-acetylneuraminate + acetate

Thus, the two substrates of this enzyme are N-acetyl-O-acetylneuraminate and H₂O, whereas its two products are N-acetylneuraminate and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase.

[edit] References

• IUBMB entry for 3.1.1.53
• BRENDA references for 3.1.1.53 (Recommended.)
• PubMed references for 3.1.1.53
• PubMed Central references for 3.1.1.53
• Google Scholar references for 3.1.1.53
• Garcia-Sastre A, Villar E, Manuguerra JC, Hannoun C, Cabezas JA (Pt 2). "Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds". Biochem. J. 273: 435–41. PMID 1991039. 
• Shukla AK and Schauer R (1982). "High performance liquid chromatography of enzymes of sialic acid metabolism". Hoppe-Seyler's Z. Physiol. Chem. 363: 1039–1040. 

[edit] External links

The CAS registry number for this enzyme class is 89400-31-7.

• IUBMB entry for 3.1.1.53

• KEGG entry for 3.1.1.53

• BRENDA entry for 3.1.1.53

• NiceZyme view of 3.1.1.53

• EC2PDB: PDB structures for 3.1.1.53

• PRIAM entry for 3.1.1.53

• PUMA2 entry for 3.1.1.53

• IntEnz: Integrated Enzyme entry for 3.1.1.53

• MetaCyc entry for 3.1.1.53

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0001681: sialate O-acetylesterase

• AMIGO entry for GO code 0001681: sialate O-acetylesterase