SHB (gene)

From Wikipedia, the free encyclopedia

Src homology 2 domain containing adaptor protein B

Identifiers

SHB; RP11-3J10.8; bA3J10.2

External IDs

OMIM: 600314 MGI: 98294 HomoloGene: 74458

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein binding
Cellular Component:	• membrane
Biological Process:	• angiogenesis • apoptosis • intracellular signaling cascade • multicellular organismal development • cell differentiation • B cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003028 (mRNA)
NP_003019 (protein)

XM_131399 (mRNA)
XP_131399 (protein)

Location

Chr 9: 37.91 - 38.06 Mb

Chr 4: 45.44 - 45.55 Mb

Pubmed search

[1]

[2]

Src homology 2 domain containing adaptor protein B, also known as SHB, is a human gene.^[1]

[edit] References

^ Entrez Gene: SHB Src homology 2 domain containing adaptor protein B.

[edit] Further reading

Karlsson T, Songyang Z, Landgren E, et al. (1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.". Oncogene 10 (8): 1475–83. PMID 7537362.
Yulug IG, Hillermann R, Fisher EM (1995). "The SHB adaptor protein maps to human chromosome 9.". Genomics 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
Welsh M, Mares J, Karlsson T, et al. (1994). "Shb is a ubiquitously expressed Src homology 2 protein.". Oncogene 9 (1): 19–27. PMID 8302579.
Karlsson T, Welsh M (1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb.". Oncogene 13 (5): 955–61. PMID 8806685.
Welsh M, Songyang Z, Frantz JD, et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.". Oncogene 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
Karlsson T, Kullander K, Welsh M (1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells.". Cell Growth Differ. 9 (9): 757–66. PMID 9751119.
Lindholm CK, Gylfe E, Zhang W, et al. (1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.". J. Biol. Chem. 274 (39): 28050–7. PMID 10488157.
Dixelius J, Larsson H, Sasaki T, et al. (2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis.". Blood 95 (11): 3403–11. PMID 10828022.
Hooshmand-Rad R, Lu L, Heldin CH, et al. (2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.". Exp. Cell Res. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.
Lu L, Annerén C, Reedquist KA, et al. (2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.". Exp. Cell Res. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504.
Diakonova M, Gunter DR, Herrington J, Carter-Su C (2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility.". J. Biol. Chem. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.
Lindholm CK, Henriksson ML, Hallberg B, Welsh M (2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.". Eur. J. Biochem. 269 (13): 3279–88. PMID 12084069.
Cross MJ, Lu L, Magnusson P, et al. (2003). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.". Mol. Biol. Cell 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMID 12181353.
Lindholm CK (2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells.". Biochem. Biophys. Res. Commun. 296 (4): 929–36. PMID 12200137.
Holmqvist K, Cross M, Riley D, Welsh M (2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells.". Cell. Signal. 15 (2): 171–9. PMID 12464388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Welsh N, Makeeva N, Welsh M (2003). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.". Mol. Med. 8 (11): 695–704. PMID 12520086.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Holmqvist K, Cross MJ, Rolny C, et al. (2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.". J. Biol. Chem. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.