SH3GL2

From Wikipedia, the free encyclopedia

SH3-domain GRB2-like 2

PDB rendering based on 1x03.

Available structures: 1x03, 1zww, 2c08, 2d4c, 2dbm

Identifiers

Symbol(s)

SH3GL2; CNSA2; EEN-B1; FLJ20276; FLJ25015; SH3D2A; SH3P4

External IDs

OMIM: 604465 MGI: 700009 HomoloGene: 20652

Gene ontology
Molecular Function:	• lipid binding • acyltransferase activity • transferase activity • identical protein binding
Cellular Component:	• cytoplasm
Biological Process:	• signal transduction • central nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003026 (mRNA)
NP_003017 (protein)

NM_019535 (mRNA)
NP_062408 (protein)

Location

Chr 9: 17.57 - 17.79 Mb

Chr 4: 84.68 - 84.86 Mb

Pubmed search

[1]

[2]

SH3-domain GRB2-like 2, also known as SH3GL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SH3GL2 SH3-domain GRB2-like 2.

[edit] Further reading

Reutens AT, Begley CG (2002). "Endophilin-1: a multifunctional protein.". Int. J. Biochem. Cell Biol. 34 (10): 1173-7. PMID 12127567.
So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563-8. PMID 9122235.
Giachino C, Lantelme E, Lanzetti L, et al. (1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system.". Genomics 41 (3): 427-34. PMID 9169142.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569-74. PMID 9238017.
Micheva KD, Ramjaun AR, Kay BK, McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin.". FEBS Lett. 414 (2): 308-12. PMID 9315708.
Micheva KD, Kay BK, McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.". J. Biol. Chem. 272 (43): 27239-45. PMID 9341169.
Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693-9. PMID 10531379.
Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559-64. PMID 10535961.
Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.". J. Biol. Chem. 274 (45): 32001-7. PMID 10542231.
So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.". Leukemia 14 (4): 594-601. PMID 10764144.
So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.". Biochem. J. 348 Pt 2: 447-58. PMID 10816441.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329-39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Ramjaun AR, Angers A, Legendre-Guillemin V, et al. (2001). "Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.". J. Biol. Chem. 276 (31): 28913-9. doi:10.1074/jbc.M103198200. PMID 11384986.
Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW (2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.". J. Biol. Chem. 277 (20): 17597-604. doi:10.1074/jbc.M111101200. PMID 11877424.
Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.". Nature 416 (6877): 183-7. doi:10.1038/416183a. PMID 11894095.
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187-90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108-15. doi:10.1074/jbc.M204019200. PMID 12034747.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666-72. doi:10.1074/jbc.M205535200. PMID 12177062.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191-6. doi:10.1073/pnas.192462299. PMID 12218189.