SH2B2

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SH2B adaptor protein 2
PDB rendering based on 1q2h.
Available structures: 1q2h, 1rpy, 1rqq, 1v5m
Identifiers
Symbol(s) SH2B2; APS
External IDs OMIM: 605300 MGI: 1345171 HomoloGene: 10309
Orthologs
Human Mouse
Entrez 10603 23921
Ensembl n/a ENSMUSG00000005057
Uniprot n/a Q6PG00
Refseq NM_020979 (mRNA)
NP_066189 (protein)		 NM_018825 (mRNA)
NP_061295 (protein)
Location n/a Chr 5: 136.5 - 136.53 Mb
Pubmed search [1] [2]

SH2B adaptor protein 2, also known as SH2B2, is a human gene.[1]

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[1]

[edit] References

  1. ^ a b Entrez Gene: SH2B2 SH2B adaptor protein 2.

[edit] Further reading

  • Yokouchi M, Suzuki R, Masuhara M, et al. (1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.". Oncogene 15 (1): 7-15. doi:10.1038/sj.onc.1201163. PMID 9233773. 
  • Glöckner G, Scherer S, Schattevoy R, et al. (1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.". Genome Res. 8 (10): 1060-73. PMID 9799793. 
  • Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons.". Neuron 21 (5): 1017-29. PMID 9856458. 
  • Yokouchi M, Wakioka T, Sakamoto H, et al. (1999). "APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.". Oncogene 18 (3): 759-67. doi:10.1038/sj.onc.1202326. PMID 9989826. 
  • Moodie SA, Alleman-Sposeto J, Gustafson TA (1999). "Identification of the APS protein as a novel insulin receptor substrate.". J. Biol. Chem. 274 (16): 11186-93. PMID 10196204. 
  • Wakioka T, Sasaki A, Mitsui K, et al. (1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.". Leukemia 13 (5): 760-7. PMID 10374881. 
  • Iseki M, Takaki S, Takatsu K (2000). "Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.". Biochem. Biophys. Res. Commun. 272 (1): 45-54. doi:10.1006/bbrc.2000.2736. PMID 10872802. 
  • O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases.". J. Biol. Chem. 277 (10): 8673-81. doi:10.1074/jbc.M109165200. PMID 11751854. 
  • Liu J, Kimura A, Baumann CA, Saltiel AR (2002). "APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.". Mol. Cell. Biol. 22 (11): 3599-609. PMID 11997497. 
  • Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.". Oncogene 21 (50): 7720-9. doi:10.1038/sj.onc.1205927. PMID 12400014. 
  • Ahn MY, Katsanakis KD, Bheda F, Pillay TS (2004). "Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling.". J. Biol. Chem. 279 (20): 21526-32. doi:10.1074/jbc.M307740200. PMID 15031295. 
  • Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.". J. Biol. Chem. 279 (37): 38881-8. doi:10.1074/jbc.M406101200. PMID 15231829. 
  • Hu J, Hubbard SR (2005). "Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.". J. Biol. Chem. 280 (19): 18943-9. doi:10.1074/jbc.M414157200. PMID 15737992. 
  • Iseki M, Kubo-Akashi C, Kwon SM, et al. (2005). "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.". Biochem. Biophys. Res. Commun. 330 (3): 1005-13. doi:10.1016/j.bbrc.2005.03.073. PMID 15809095. 
  • Katsanakis KD, Pillay TS (2006). "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.". J. Biol. Chem. 280 (45): 37827-32. doi:10.1074/jbc.M505959200. PMID 16141217. 
  • Li M, Li Z, Morris DL, Rui L (2007). "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling.". Endocrinology 148 (4): 1615-21. doi:10.1210/en.2006-1010. PMID 17204555. 
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