SGPL1

From Wikipedia, the free encyclopedia

Sphingosine-1-phosphate lyase 1

Identifiers

SGPL1; FLJ13811; KIAA1252; SPL

External IDs

OMIM: 603729 MGI: 1261415 HomoloGene: 2897

Gene ontology
Molecular Function:	• sphinganine-1-phosphate aldolase activity • lyase activity • carboxy-lyase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• lipid metabolic process • ceramide metabolic process • apoptosis • carboxylic acid metabolic process • sphingolipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003901 (mRNA)
NP_003892 (protein)

NM_009163 (mRNA)
NP_033189 (protein)

Location

Chr 10: 72.25 - 72.31 Mb

Chr 10: 60.49 - 60.52 Mb

Pubmed search

[1]

[2]

Sphingosine-1-phosphate lyase 1, also known as SGPL1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1.

[edit] Further reading

Van Veldhoven PP, Mannaerts GP (1991). "Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver.". J. Biol. Chem. 266 (19): 12502-7. PMID 2061324.
Zhou J, Saba JD (1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.". Biochem. Biophys. Res. Commun. 242 (3): 502-7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462.
Van Veldhoven PP, Gijsbers S, Mannaerts GP, et al. (2000). "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).". Biochim. Biophys. Acta 1487 (2-3): 128-34. PMID 11018465.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Reiss U, Oskouian B, Zhou J, et al. (2004). "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.". J. Biol. Chem. 279 (2): 1281-90. doi:10.1074/jbc.M309646200. PMID 14570870.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.". Anal. Biochem. 354 (2): 279-89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Oskouian B, Sooriyakumaran P, Borowsky AD, et al. (2007). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.". Proc. Natl. Acad. Sci. U.S.A. 103 (46): 17384-9. doi:10.1073/pnas.0600050103. PMID 17090686.