SFXN1

From Wikipedia, the free encyclopedia

Sideroflexin 1

Identifiers

SFXN1; FLJ12876

External IDs

Gene ontology
Molecular Function:	• iron ion binding • cation transmembrane transporter activity
Cellular Component:	• mitochondrion • mitochondrial inner membrane • membrane • integral to membrane
Biological Process:	• cation transport • iron ion transport • erythrocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022754 (mRNA)
NP_073591 (protein)

NM_027324 (mRNA)
NP_081600 (protein)

Location

Chr 5: 174.85 - 174.89 Mb

Chr 13: 54.08 - 54.12 Mb

Pubmed search

[1]

[2]

Sideroflexin 1, also known as SFXN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SFXN1 sideroflexin 1.

[edit] Further reading

Kaplan RS, Mayor JA (1994). "Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria.". J. Bioenerg. Biomembr. 25 (5): 503–14. PMID 8132490.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Fleming MD, Campagna DR, Haslett JN, et al. (2001). "A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.". Genes Dev. 15 (6): 652–7. doi:10.1101/gad.873001. PMID 11274051.
Zara V, Giudetti AM, Siculella L, et al. (2001). "Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats.". Eur. J. Biochem. 268 (22): 5734–9. PMID 11722557.
Miyake S, Yamashita T, Taniguchi M, et al. (2002). "Identification and characterization of a novel mitochondrial tricarboxylate carrier.". Biochem. Biophys. Res. Commun. 295 (2): 463–8. PMID 12150972.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Giudetti AM, Sabetta S, di Summa R, et al. (2004). "Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria.". J. Lipid Res. 44 (11): 2135–41. doi:10.1194/jlr.M300237-JLR200. PMID 14634051.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Siculella L, Damiano F, Sabetta S, Gnoni GV (2005). "n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms.". J. Lipid Res. 45 (7): 1333–40. doi:10.1194/jlr.M400061-JLR200. PMID 15060089.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Siculella L, Sabetta S, Damiano F, et al. (2005). "Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver.". FEBS Lett. 578 (3): 280–4. doi:10.1016/j.febslet.2004.11.014. PMID 15589833.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.