SFRS10

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Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)

PDB rendering based on 2cqc.

Available structures: 2cqc

Identifiers

Symbol(s)

SFRS10; DKFZp686F18120; Htra2-beta; SRFS10; TRA2-BETA; TRA2B

External IDs

OMIM: 602719 MGI: 106016 HomoloGene: 20965

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • protein binding • RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus
Biological Process:	• nuclear mRNA splicing, via spliceosome • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004593 (mRNA)
NP_004584 (protein)

NM_009186 (mRNA)
NP_033212 (protein)

Location

Chr 3: 187.12 - 187.14 Mb

n/a

Pubmed search

[1]

[2]

Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila), also known as SFRS10, is a human gene.^[1]

[edit] References

^ Entrez Gene: SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila).

[edit] Further reading

Matsuo N, Ogawa S, Imai Y, et al. (1996). "Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation.". J. Biol. Chem. 270 (47): 28216–22. PMID 7499316.
Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing.". DNA Cell Biol. 16 (6): 679–90. PMID 9212162.
Imai Y, Matsuo N, Ogawa S, et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation.". Brain Res. Mol. Brain Res. 53 (1-2): 33–40. PMID 9473574.
Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.". Cell 93 (1): 139–48. PMID 9546399.
Nayler O, Cap C, Stamm S (1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform.". Genomics 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. PMID 10339552.
Lai MC, Lin RI, Huang SY, et al. (2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins.". J. Biol. Chem. 275 (11): 7950–7. PMID 10713112.
Venables JP, Elliott DJ, Makarova OV, et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.". Hum. Mol. Genet. 9 (5): 685–94. PMID 10749975.
Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy.". Hum. Genet. 107 (6): 554–8. PMID 11153908.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1.". Hum. Mol. Genet. 11 (5): 577–87. PMID 11875052.
Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1.". Hum. Mol. Genet. 11 (17): 2037–49. PMID 12165565.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer.". Biochim. Biophys. Acta 1625 (2): 141–52. PMID 12531473.
El Yazidi-Belkoura I, Adriaenssens E, Dollé L, et al. (2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells.". J. Biol. Chem. 278 (19): 16952–6. doi:10.1074/jbc.M300631200. PMID 12604596.
Jiang Z, Tang H, Havlioglu N, et al. (2003). "Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta.". J. Biol. Chem. 278 (21): 18997–9007. doi:10.1074/jbc.M301800200. PMID 12649279.
Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern.". Cell Biol. Int. 27 (6): 491–6. PMID 12798777.
Helmken C, Hofmann Y, Schoenen F, et al. (2004). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1.". Hum. Genet. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID 14520560.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.