SFRP5

From Wikipedia, the free encyclopedia

Secreted frizzled-related protein 5

Identifiers

External IDs

OMIM: 604158 MGI: 1860298 HomoloGene: 2268

Gene ontology
Cellular Component:	• extracellular space
Biological Process:	• apoptosis • establishment and/or maintenance of cell polarity • signal transduction • multicellular organismal development • visual perception • anatomical structure morphogenesis • Wnt receptor signaling pathway • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003015 (mRNA)
NP_003006 (protein)

NM_018780 (mRNA)
NP_061250 (protein)

Location

Chr 10: 99.52 - 99.52 Mb

Chr 19: 42.25 - 42.26 Mb

Pubmed search

[1]

[2]

Secreted frizzled-related protein 5, also known as SFRP5, is a human gene.^[1]

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.^[1]

[edit] References

^ ^a ^b Entrez Gene: SFRP5 secreted frizzled-related protein 5.

[edit] Further reading

Veeck J, Geisler C, Noetzel E, et al. (2008). "Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis.". Carcinogenesis.. doi:10.1093/carcin/bgn076. PMID 18356147.
Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.". Clin. Cancer Res. 12 (7 Pt 1): 2109-16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chang JT, Esumi N, Moore K, et al. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.". Hum. Mol. Genet. 8 (4): 575-83. PMID 10072424.
Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas.". Biochem. Biophys. Res. Commun. 247 (2): 287-93. doi:10.1006/bbrc.1998.8784. PMID 9642118.
Melkonyan HS, Chang WC, Shapiro JP, et al. (1998). "SARPs: a family of secreted apoptosis-related proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13636-41. PMID 9391078.
Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859-63. PMID 9096311.