SFRP4

From Wikipedia, the free encyclopedia

Secreted frizzled-related protein 4

Identifiers

SFRP4; FRP-4; FRPHE; MGC26498

External IDs

OMIM: 606570 MGI: 892010 HomoloGene: 2267

Gene ontology
Cellular Component:	• extracellular space
Biological Process:	• signal transduction • embryo implantation • Wnt receptor signaling pathway • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003014 (mRNA)
NP_003005 (protein)

NM_016687 (mRNA)
NP_057896 (protein)

Location

Chr 7: 37.91 - 37.92 Mb

Chr 13: 19.63 - 19.64 Mb

Pubmed search

[1]

[2]

Secreted frizzled-related protein 4, also known as SFRP4, is a human gene.^[1]

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.^[1]

[edit] References

^ ^a ^b Entrez Gene: SFRP4 secreted frizzled-related protein 4.

[edit] Further reading

Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. PMID 9096311.
Wolf V, Ke G, Dharmarajan AM, et al. (1998). "DDC-4, an apoptosis-associated gene, is a secreted frizzled relative.". FEBS Lett. 417 (3): 385–9. PMID 9409757.
Abu-Jawdeh G, Comella N, Tomita Y, et al. (1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.". Lab. Invest. 79 (4): 439–47. PMID 10211996.
Schumann H, Holtz J, Zerkowski HR, Hatzfeld M (2000). "Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.". Cardiovasc. Res. 45 (3): 720–8. PMID 10728394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Berndt T, Craig TA, Bowe AE, et al. (2003). "Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.". J. Clin. Invest. 112 (5): 785–94. doi:10.1172/JCI200318563. PMID 12952927.
Wissmann C, Wild PJ, Kaiser S, et al. (2003). "WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.". J. Pathol. 201 (2): 204–12. doi:10.1002/path.1449. PMID 14517837.
Horvath LG, Henshall SM, Kench JG, et al. (2004). "Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro.". Clin. Cancer Res. 10 (2): 615–25. PMID 14760084.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
He B, Lee AY, Dadfarmay S, et al. (2005). "Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.". Cancer Res. 65 (3): 743–8. PMID 15705870.
Berndt TJ, Bielesz B, Craig TA, et al. (2006). "Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells.". Pflugers Arch. 451 (4): 579–87. doi:10.1007/s00424-005-1495-2. PMID 16151791.
Feng Han Q, Zhao W, Bentel J, et al. (2006). "Expression of sFRP-4 and beta-catenin in human colorectal carcinoma.". Cancer Lett. 231 (1): 129–37. doi:10.1016/j.canlet.2005.01.026. PMID 16356838.
Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.
Horvath LG, Lelliott JE, Kench JG, et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.". Prostate 67 (10): 1081–90. doi:10.1002/pros.20607. PMID 17476687.