SFRP2

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Secreted frizzled-related protein 2
Identifiers
Symbol(s) SFRP2; FRP-2; SARP1; SDF-5
External IDs OMIM: 604157 MGI: 108078 HomoloGene: 56438
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6423 20319
Ensembl ENSG00000145423 ENSMUSG00000027996
Uniprot Q96HF1 Q3UI35
Refseq NM_003013 (mRNA)
NP_003004 (protein)		 NM_009144 (mRNA)
NP_033170 (protein)
Location Chr 4: 154.92 - 154.93 Mb Chr 3: 83.85 - 83.86 Mb
Pubmed search [1] [2]

Secreted frizzled-related protein 2, also known as SFRP2, is a human gene.[1]

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[1]

[edit] References

  1. ^ a b Entrez Gene: SFRP2 secreted frizzled-related protein 2.

[edit] Further reading

  • Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. PMID 9096311. 
  • Melkonyan HS, Chang WC, Shapiro JP, et al. (1998). "SARPs: a family of secreted apoptosis-related proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13636–41. PMID 9391078. 
  • Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas.". Biochem. Biophys. Res. Commun. 247 (2): 287–93. doi:10.1006/bbrc.1998.8784. PMID 9642118. 
  • Lescher B, Haenig B, Kispert A (1999). "sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney.". Dev. Dyn. 213 (4): 440–51. doi:10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6. PMID 9853965. 
  • Chang JT, Esumi N, Moore K, et al. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.". Hum. Mol. Genet. 8 (4): 575–83. PMID 10072424. 
  • Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.". Development 127 (1): 109–18. PMID 10654605. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Brophy PD, Lang KM, Dressler GR (2004). "The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor.". J. Biol. Chem. 278 (52): 52401–5. doi:10.1074/jbc.M305614200. PMID 14561758. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Lee JL, Lin CT, Chueh LL, Chang CJ (2004). "Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis.". J. Biol. Chem. 279 (15): 14602–9. doi:10.1074/jbc.M309008200. PMID 14709558. 
  • Müller HM, Oberwalder M, Fiegl H, et al. (2004). "Methylation changes in faecal DNA: a marker for colorectal cancer screening?". Lancet 363 (9417): 1283–5. doi:10.1016/S0140-6736(04)16002-9. PMID 15094274. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Clément G, Braunschweig R, Pasquier N, et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus.". Oncogene 25 (21): 3084–92. doi:10.1038/sj.onc.1209338. PMID 16407829. 
  • Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Huang ZH, Li LH, Yang F, Wang JF (2007). "Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.". World J. Gastroenterol. 13 (6): 950–4. PMID 17352030. 
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