SFPQ

From Wikipedia, the free encyclopedia

Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)

Identifiers

SFPQ; PSF; POMP100

External IDs

OMIM: 605199 MGI: 1918764 HomoloGene: 3714

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • RNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• DNA repair • DNA recombination • transcription • regulation of transcription, DNA-dependent • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005066 (mRNA)
NP_005057 (protein)

XM_981759 (mRNA)
XP_986853 (protein)

Location

Chr 1: 35.41 - 35.43 Mb

Chr 4: 126.52 - 126.53 Mb

Pubmed search

[1]

[2]

Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated), also known as SFPQ, is a human gene.^[1]

[edit] References

^ Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated).

[edit] Further reading

Shav-Tal Y, Zipori D (2002). "PSF and p54(nrb)/NonO--multi-functional nuclear proteins.". FEBS Lett. 531 (2): 109–14. PMID 12417296.
Gower HJ, Moore SE, Dickson G, et al. (1990). "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody.". Development 105 (4): 723–31. PMID 2480877.
Gozani O, Patton JG, Reed R (1994). "A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction.". EMBO J. 13 (14): 3356–67. PMID 8045264.
Zhang WW, Zhang LX, Busch RK, et al. (1993). "Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.". Biochem. J. 290 ( Pt 1): 267–72. PMID 8439294.
Patton JG, Porro EB, Galceran J, et al. (1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor.". Genes Dev. 7 (3): 393–406. PMID 8449401.
Clark J, Lu YJ, Sidhar SK, et al. (1997). "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.". Oncogene 15 (18): 2233–9. doi:10.1038/sj.onc.1201394. PMID 9393982.
Teigelkamp S, Mundt C, Achsel T, et al. (1998). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.". RNA 3 (11): 1313–26. PMID 9409622.
Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.". J. Biol. Chem. 273 (41): 26261–4. PMID 9756848.
Lutz CS, Cooke C, O'Connor JP, et al. (1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.". RNA 4 (12): 1493–9. PMID 9848648.
Meissner M, Dechat T, Gerner C, et al. (2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB.". J. Cell. Biochem. 76 (4): 559–66. PMID 10653975.
Urban RJ, Bodenburg Y, Kurosky A, et al. (2000). "Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element.". Mol. Endocrinol. 14 (6): 774–82. PMID 10847580.
Straub T, Knudsen BR, Boege F (2000). "PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices.". Biochemistry 39 (25): 7552–8. PMID 10858305.
Akhmedov AT, Lopez BS (2000). "Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.". Nucleic Acids Res. 28 (16): 3022–30. PMID 10931916.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
Dye BT, Patton JG (2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles.". Exp. Cell Res. 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID 11161712.
Mathur M, Tucker PW, Samuels HH (2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.". Mol. Cell. Biol. 21 (7): 2298–311. doi:10.1128/MCB.21.7.2298-2311.2001. PMID 11259580.
Shav-Tal Y, Cohen M, Lapter S, et al. (2002). "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.". Mol. Biol. Cell 12 (8): 2328–40. PMID 11514619.
Zhang Z, Carmichael GG (2001). "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.". Cell 106 (4): 465–75. PMID 11525732.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Sewer MB, Nguyen VQ, Huang CJ, et al. (2002). "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.". Endocrinology 143 (4): 1280–90. PMID 11897684.