SETMAR

From Wikipedia, the free encyclopedia

SET domain and mariner transposase fusion gene

Identifiers

SETMAR; METNASE

External IDs

OMIM: 609834 MGI: 1921979 HomoloGene: 68519

Gene ontology
Molecular Function:	• DNA binding • transposase activity • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• DNA repair • transposition, DNA-mediated • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006515 (mRNA)
NP_006506 (protein)

XM_001001353 (mRNA)
XP_001001353 (protein)

Location

Chr 3: 4.32 - 4.33 Mb

Chr 6: 108.03 - 108.04 Mb

Pubmed search

[1]

[2]

SET domain and mariner transposase fusion gene, also known as SETMAR, is a human gene.^[1]

[edit] References

^ Entrez Gene: SETMAR SET domain and mariner transposase fusion gene.

[edit] Further reading

Berry R, Stevens TJ, Walter NA, et al. (1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map.". Nat. Genet. 10 (4): 415-23. doi:10.1038/ng0895-415. PMID 7670491.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Robertson HM, Zumpano KL (1998). "Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome.". Gene 205 (1-2): 203-17. PMID 9461395.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lee SH, Oshige M, Durant ST, et al. (2006). "The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 18075-80. doi:10.1073/pnas.0503676102. PMID 16332963.
Cordaux R, Udit S, Batzer MA, Feschotte C (2006). "Birth of a chimeric primate gene by capture of the transposase gene from a mobile element.". Proc. Natl. Acad. Sci. U.S.A. 103 (21): 8101-6. doi:10.1073/pnas.0601161103. PMID 16672366.
Keravala A, Liu D, Lechman ER, et al. (2007). "Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo.". Hum. Gene Ther. 17 (10): 1006-18. doi:10.1089/hum.2006.17.ft-245. PMID 16989604.
Liu D, Bischerour J, Siddique A, et al. (2007). "The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase.". Mol. Cell. Biol. 27 (3): 1125-32. doi:10.1128/MCB.01899-06. PMID 17130240.
Miskey C, Papp B, Mátés L, et al. (2007). "The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends.". Mol. Cell. Biol. 27 (12): 4589-600. doi:10.1128/MCB.02027-06. PMID 17403897.
Roman Y, Oshige M, Lee YJ, et al. (2007). "Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity.". Biochemistry 46 (40): 11369-76. doi:10.1021/bi7005477. PMID 17877369.