Talk:Serratia marcescens

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Contents 1 Chiron link 2 colour changes according to growth temperatures 3 why colour changes according to growth temperatures 4 References

[edit] Chiron link

• I've pulled the Chiron link (http://chiron.com/041008_testimony.pdf); it appears to be dead and my search for an archived copy (Wayback Machine, etc) didn't turn up anything. If anyone can find a link, we can stick it back in. -- MarcoTolo 21:54, 3 May 2006 (UTC)

[edit] colour changes according to growth temperatures

Can any of you suggest a reason why the colonies of Serratia are different colours at different growth temperatures? If you could, please add the information to this page. Thx.

[edit] why colour changes according to growth temperatures

The red pigment produced by Serratia marcescens is prodigiosin. Its production, and that of another lipid (the surfactant serrawettin W1), is regulated by the product of a gene hexS. Mutants lacking HexS over-produce the first enzyme in prodigiosin production, encoded by the pigA gene (and the swrW gene, implicated in the synthesis of serrawettin W1^[1]. Presumably, this gene is temperature-sensitive.

Prodigiosin is a secondary metabolite of Serratia marcescens and its production is regulated by changes in growth medium as well as by teperature shifts.

[edit] References

1. ^ TanikawaT, Nakagawa Y, Matsuyama T (2006). "Transcriptional downregulator hexS Controlling Prodigiosin and serrawettin W1 biosynthesis in Serratia marcescens.". Microbiol Immunol 50 (8): 587-96. PubMed.